Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.
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Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial BioenergeticsMouse models of Parkinson's disease associated with mitochondrial dysfunctionNew insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyondAfter the banquet: mitochondrial biogenesis, mitophagy, and cell survivalDysregulation of autophagy and mitochondrial function in Parkinson's diseasePGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease.A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset.Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf.Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerizationPGC-1α activity in nigral dopamine neurons determines vulnerability to α-synucleinNRF2 promotes neuronal survival in neurodegeneration and acute nerve damage.The Neuroprotective Effect of Tetramethylpyrazine Against Contusive Spinal Cord Injury by Activating PGC-1α in Rats.Thiol-redox signaling, dopaminergic cell death, and Parkinson's diseasePromotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport ChainLack of Genetic Associations of PPAR-γ and PGC-1α with Alzheimer's Disease and Parkinson's Disease with Dementia.Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons.Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR- γ Agonist against MPTP.PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model.Foxa1 is essential for development and functional integrity of the subthalamic nucleus.Gene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease?The impact of mitochondrial DNA and nuclear genes related to mitochondrial functioning on the risk of Parkinson's disease.PGC-1α: a master gene that is hard to master.Peroxisome proliferator-activated receptor-γ cofactors in neurodegeneration.Signaling pathway cross talk in Alzheimer's diseasePPARγ and PGC-1α as therapeutic targets in Parkinson's.Impaired mitochondrial homeostasis and neurodegeneration: towards new therapeutic targets?The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?Neuroprotective effects of geniposide on Alzheimer's disease pathology.Current disease modifying approaches to treat Parkinson's disease.SUMO-regulated mitochondrial function in Parkinson's disease.PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity.Gene therapy targeting mitochondrial pathway in Parkinson's disease.Treatments and compositions targeting α-synuclein: a patent review (2010-2016).Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells.Peroxisome proliferator-activated receptor-γ coactivator-1α mediates neuroprotection against excitotoxic brain injury in transgenic mice: role of mitochondria and X-linked inhibitor of apoptosis protein.Caloric Restriction and the Nutrient-Sensing PGC-1α in Mitochondrial Homeostasis: New Perspectives in Neurodegeneration.Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity.The Interaction of Mitochondrial Biogenesis and Fission/Fusion Mediated by PGC-1α Regulates Rotenone-Induced Dopaminergic Neurotoxicity.PGC1α: Friend or Foe in Cancer?
P2860
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P2860
Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Sustained expression of PGC-1α ...... impairs dopaminergic function.
@ast
Sustained expression of PGC-1α ...... impairs dopaminergic function.
@en
type
label
Sustained expression of PGC-1α ...... impairs dopaminergic function.
@ast
Sustained expression of PGC-1α ...... impairs dopaminergic function.
@en
prefLabel
Sustained expression of PGC-1α ...... impairs dopaminergic function.
@ast
Sustained expression of PGC-1α ...... impairs dopaminergic function.
@en
P2093
P2860
P356
P1476
Sustained expression of PGC-1α ...... impairs dopaminergic function
@en
P2093
J Dusonchet
P Aebischer
S Lengacher
P2860
P304
P356
10.1093/HMG/DDR618
P577
2012-01-12T00:00:00Z