Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation.
about
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Peeling away the layers of ubiquitin signaling complexities with synthetic ubiquitin-protein conjugates.Synthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational ModificationsNon-degradative Ubiquitination of Protein Kinases.Cysteine promoted C-terminal hydrazinolysis of native peptides and proteins.The challenge of producing ubiquitinated proteins for structural studiesLabeling proteins with fluorophore/thioamide Förster resonant energy transfer pairs by combining unnatural amino acid mutagenesis and native chemical ligationRole of α-synuclein in inducing innate and adaptive immunity in Parkinson disease.Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerizationChemical Methods for Encoding and Decoding of Posttranslational ModificationsInhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology.Site-specific differences in proteasome-dependent degradation of monoubiquitinated α-synuclein.Chemical Protein Ubiquitylation with Preservation of the Native Cysteine Residues.Chemistry and biology of the ubiquitin signal.Chemical strategies to understand the language of ubiquitin signaling.Ubiquitin system: direct effects join the signaling.Using chemistry to investigate the molecular consequences of protein ubiquitylation.Ubiquitination in disease pathogenesis and treatment.Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins.Chemical ubiquitination for decrypting a cellular code.O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation.DNA-binding regulates site-specific ubiquitination of IRF-1.A covalently reactive group-modified peptide that specifically reacts with lysine16 in amyloid β.Exploring chemoselective S-to-N acyl transfer reactions in synthesis and chemical biology.Biological and Physicochemical Functions of Ubiquitylation Revealed by Synthetic Chemistry Approaches.Label-Free and Real-Time Detection of Protein Ubiquitination with a Biological NanoporeIntrinsic site-selectivity of ubiquitin dimer formation.Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein.A molecular engineering toolbox for the structural biologist.Rpn11-mediated ubiquitin processing in an ancestral archaeal ubiquitination system
P2860
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P2860
Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Semisynthetic, site-specific u ...... ential effects on aggregation.
@ast
Semisynthetic, site-specific u ...... ential effects on aggregation.
@en
type
label
Semisynthetic, site-specific u ...... ential effects on aggregation.
@ast
Semisynthetic, site-specific u ...... ential effects on aggregation.
@en
prefLabel
Semisynthetic, site-specific u ...... ential effects on aggregation.
@ast
Semisynthetic, site-specific u ...... ential effects on aggregation.
@en
P2093
P2860
P356
P1476
Semisynthetic, site-specific u ...... ential effects on aggregation.
@en
P2093
Abhinav Dhall
Champak Chatterjee
Franziska Meier
Jobin Varkey
Matthew R Pratt
Nicholas P Marotta
Ralf Langen
Tharindumala Abeywardana
P2860
P304
P356
10.1021/JA300094R
P407
P577
2012-03-14T00:00:00Z