NMR studies of hexaacylated endotoxin bound to wild-type and F126A mutant MD-2 and MD-2·TLR4 ectodomain complexes.
about
Computational Approaches to Toll-Like Receptor 4 Modulation"Rules of Engagement" of Protein-Glycoconjugate Interactions: A Molecular View Achievable by using NMR Spectroscopy and Molecular ModelingToll-like receptor 4 (TLR4) modulation by synthetic and natural compounds: an update.Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins.Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid AInsights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection.Energetics of Endotoxin Recognition in the Toll-Like Receptor 4 Innate Immune Response.Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers.Radioiodination of an endotoxin·MD-2 complex generates a novel sensitive, high-affinity ligand for TLR4.Conformationally constrained lipid A mimetics for exploration of structural basis of TLR4/MD-2 activation by lipopolysaccharide.The structural basis for endotoxin-induced allosteric regulation of the Toll-like receptor 4 (TLR4) innate immune receptor.A structural insight into the negative effects of opioids in analgesia by modulating the TLR4 signaling: An in silico approach.Small-Molecule Carbohydrate-Based Immunostimulants.Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold.Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship.Gut-homing Δ42PD1(+)Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection.Development of αGlcN(1↔1)αMan-based lipid A mimetics as a novel class of potent Toll-like receptor 4 agonists.Identification of single nucleotide polymorphisms in hematopoietic cell transplant patients affecting early recognition of, and response to, endotoxin.The Role of Carbohydrates in the Lipopolysaccharide (LPS)/Toll-Like Receptor 4 (TLR4) Signalling.High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles.Computational Insight Into the Structural Organization of Full-Length Toll-Like Receptor 4 Dimer in a Model Phospholipid Bilayer.Diverse pro-inflammatory endotoxin recognition systems of mammalian innate immunity.
P2860
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P2860
NMR studies of hexaacylated endotoxin bound to wild-type and F126A mutant MD-2 and MD-2·TLR4 ectodomain complexes.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
NMR studies of hexaacylated en ...... D-2·TLR4 ectodomain complexes.
@ast
NMR studies of hexaacylated en ...... D-2·TLR4 ectodomain complexes.
@en
type
label
NMR studies of hexaacylated en ...... D-2·TLR4 ectodomain complexes.
@ast
NMR studies of hexaacylated en ...... D-2·TLR4 ectodomain complexes.
@en
prefLabel
NMR studies of hexaacylated en ...... D-2·TLR4 ectodomain complexes.
@ast
NMR studies of hexaacylated en ...... D-2·TLR4 ectodomain complexes.
@en
P2860
P50
P356
P1476
NMR studies of hexaacylated en ...... D-2·TLR4 ectodomain complexes.
@en
P2093
Rachel L Phillips
P2860
P304
16346-16355
P356
10.1074/JBC.M112.343467
P407
P577
2012-03-20T00:00:00Z