Evidence that behavioral phenotypes of morphine in β-arr2-/- mice are due to the unmasking of JNK signaling.
about
Opioid receptor desensitization: mechanisms and its link to toleranceβ-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons.Change in functional selectivity of morphine with the development of antinociceptive tolerance.Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors.Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase.Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms.Morphine desensitization and cellular tolerance are distinguished in rat locus ceruleus neurons.Ligand-directed signalling within the opioid receptor family.β-Arrestin-2 modulates radiation-induced intestinal crypt progenitor/stem cell injury.Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and DownregulationEfficacy and ligand bias at the μ-opioid receptor.β-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia.The μ-opioid receptor: an electrophysiologist's perspective from the sharp end.Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src.
P2860
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P2860
Evidence that behavioral phenotypes of morphine in β-arr2-/- mice are due to the unmasking of JNK signaling.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Evidence that behavioral pheno ...... he unmasking of JNK signaling.
@ast
Evidence that behavioral pheno ...... he unmasking of JNK signaling.
@en
type
label
Evidence that behavioral pheno ...... he unmasking of JNK signaling.
@ast
Evidence that behavioral pheno ...... he unmasking of JNK signaling.
@en
prefLabel
Evidence that behavioral pheno ...... he unmasking of JNK signaling.
@ast
Evidence that behavioral pheno ...... he unmasking of JNK signaling.
@en
P2093
P2860
P356
P1476
Evidence that behavioral pheno ...... the unmasking of JNK signaling
@en
P2093
Christopher Evans
Cui-Wei Xie
Nina Desai
Onyemachi Egbuta
Wendy Walwyn
P2860
P2888
P304
P356
10.1038/NPP.2012.42
P407
P577
2012-04-11T00:00:00Z