Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
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Fundamentals of cancer metabolismMitochondrial metabolic remodeling in response to genetic and environmental perturbationsMitochondria in Cancer Energy Metabolism: Culprits or Bystanders?Hypoxia and metabolic adaptation of cancer cellsOncometabolites: Unconventional triggers of oncogenic signalling cascadesMitochondrial dysfunction remodels one-carbon metabolism in human cellsMitochondrial Deficiencies in the Predisposition to ParagangliomaMass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio.Amplification of USP13 drives ovarian cancer metabolism.Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transitionTumour microenvironment factors shaping the cancer metabolism landscape.Mitochondria play an important role in the cell proliferation suppressing activity of berberine.Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells.Mitochondria and the hallmarks of cancer.The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate-Lactate Exchange in BRAF-Mutant Human Melanoma Cells.Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells.Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells.Mitochondria and Cancer.Mitochondrial pyruvate carrier function and cancer metabolism.Altered metabolite levels in cancer: implications for tumour biology and cancer therapy.Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM).Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.Is There a Therapeutic Window for Metabolism-Based Cancer Therapies?Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism.MCbiclust: a novel algorithm to discover large-scale functionally related gene sets from massive transcriptomics data collectionsSuccinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors.PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.Aerobic Glycolysis and the Warburg Effect. An Unexplored Realm in the Search for Fibrosis Therapies?Rethinking glutamine addiction.CHO Cells adapted to inorganic phosphate limitation show higher growth and higher pyruvate carboxylase flux in phosphate replete conditions.Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease.Targeting Metabolism for Cancer Therapy.Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells.GATOR1 regulates nitrogenic cataplerotic reactions of the mitochondrial TCA cycle.SDHB downregulation facilitates the proliferation and invasion of colorectal cancer through AMPK functions excluding those involved in the modulation of aerobic glycolysis.Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma.
P2860
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P2860
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
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name
Pyruvate carboxylation enables ...... orting aspartate biosynthesis.
@ast
Pyruvate carboxylation enables ...... orting aspartate biosynthesis.
@en
type
label
Pyruvate carboxylation enables ...... orting aspartate biosynthesis.
@ast
Pyruvate carboxylation enables ...... orting aspartate biosynthesis.
@en
prefLabel
Pyruvate carboxylation enables ...... orting aspartate biosynthesis.
@ast
Pyruvate carboxylation enables ...... orting aspartate biosynthesis.
@en
P2093
P2860
P4510
P50
P356
P1433
P1476
Pyruvate carboxylation enables ...... porting aspartate biosynthesis
@en
P2093
Alexei Vazquez
Colin Nixon
David Stevenson
Douglas Strathdee
Elaine D MacKenzie
Gabriela Kalna
Gillian MacKay
Liang Zheng
Niels J F van den Broek
Simone Cardaci
P2860
P2888
P304
P356
10.1038/NCB3233
P577
2015-08-24T00:00:00Z