Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P - Wikidata - thesis-toulmin - TriplyDB

Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P

Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P

http://www.wikidata.org/entity/Q36166728

about

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human disease Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene.Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression.Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1.Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time.Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes.The role of phosphoinositides in synapse function.Mice Deficient in lysophosphatidic acid acyltransferase delta (Lpaatδ)/acylglycerophosphate acyltransferase 4 (Agpat4) Have Impaired Learning and Memory.Calcium phosphate transfection of primary hippocampal neurons.Phosphatidylinositol 3,5-Bisphosphate-Rich Membrane Domains in Endosomes and Lysosomes.PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages.PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides.The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway.Neuropathology of childhood-onset basal ganglia degeneration caused by mutation of VAC14.Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor.Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons.

P2860

Q24617439-EAD23824-E8D6-4947-8B94-74263AFB868B Q26823539-67F915DC-AAF5-43F1-A10D-10C36B60D430 Q26852772-DC66CB5B-BD42-4320-8EB5-25A8ACA7E7FD Q27331666-CDBCD878-7C7A-4E89-A12A-6B1B87AE9E2F Q30560982-E05AD1B4-8EE5-4248-979C-1B6093CC1F21 Q30696655-C8218B80-2339-4EDD-B76F-CC462A5F74FB Q34526188-A3F2EA91-BE2C-469C-9A09-20CB80F81698 Q34616591-8F09E039-0661-4BAE-B944-A2D7394EF784 Q36712621-4910EA24-DEEA-439B-A185-A19ED3769B53 Q36812142-A9017623-54F4-4D10-BB03-642BEE9FC252 Q37395800-0CAD2042-F7D2-4D0B-A3C0-437347FBB771 Q38123475-22C53DB6-7BBA-427E-B8D9-A638D0F35D5C Q38220785-27EC5C67-5CB0-498F-B51F-1B83DA61C14C Q38625051-75D75ADE-B7B8-4F5F-A1A0-58D144FDF2F2 Q38796013-750E7335-CBF9-425C-988D-D01C71892E06 Q38819806-1C334CA2-50BE-45DE-A543-DC218FCF752D Q38973926-0C57F770-4B0B-4F67-9283-1CAEA4B0DFD4 Q39182894-17CFDAF5-B814-4A61-9E1B-0FC3A08E7DC2 Q40372975-37421819-4DF1-4A0B-A536-62377804FB31 Q47236332-8CF539D8-3D88-4A67-B6D3-65CBCC99F23A Q52315057-6F6A4D10-CF52-41CA-B86B-1A515D82D535 Q52665066-931C762F-FE45-4F0E-9C54-15BB7AB51B6D

P2860

Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P

http://www.wikidata.org/entity/Q36166728

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Modulation of synaptic functio ...... nositides PI(3,5)P₂ and PI(5)P

@ast

Modulation of synaptic functio ...... nositides PI(3,5)P₂ and PI(5)P

@en

type

label

Modulation of synaptic functio ...... nositides PI(3,5)P₂ and PI(5)P

@ast

Modulation of synaptic functio ...... nositides PI(3,5)P₂ and PI(5)P

@en

prefLabel

Modulation of synaptic functio ...... nositides PI(3,5)P₂ and PI(5)P

@ast

Modulation of synaptic functio ...... nositides PI(3,5)P₂ and PI(5)P

@en

P1433

Q36166728-7EC278CB-D8FF-4278-A72A-0E2DB3ADCAD0

P1476

Q36166728-4F0FF809-3A0E-4A95-8F4B-0938326A7B91

P2093

Q36166728-078CBE74-4972-463E-AA9A-A790B2E9ED1F

Q36166728-312815C0-908F-4E18-8EC9-AEE9663A2D50

Q36166728-5019ABF3-A3A9-4964-A04C-77EBDEBD624C

Q36166728-502E9154-E514-4104-BC0E-6A813624BD38

Q36166728-531BB037-B2F6-43AA-A5A6-0FD9D09F9284

Q36166728-621CD885-FFFD-4DB9-A222-C7532E0A35AE

P2860

Q36166728-02F6C925-1182-4224-A656-0C46AB045432

Q36166728-06464A4A-295A-4A6A-A270-585ADF3AA146

Q36166728-064BBCC8-72EB-479C-8489-794E22C36EBE

Q36166728-07E51ED8-FF3B-45DE-93B2-18BF107D407C

Q36166728-10B43D17-C9C0-46AD-8439-A1098F60DE65

Q36166728-14607DC4-F5B5-4CE5-AB7B-9380B3CE596A

Q36166728-181743F5-8AFC-40DD-B49E-9F6D042583D1

Q36166728-1962C210-1C7C-40DE-8B13-3C53F22215EE

Q36166728-1AB0EF0B-02B0-4098-9977-D3AB882EAB30

Q36166728-1FC0C0E9-F869-40AD-A191-87380EF6FDC8

P304

Q36166728-FC046DAA-8CFD-48FA-B5AD-0212DAC13FB7

P31

Q36166728-D2FAC598-1384-4B67-8F4F-3D61E21AE206

P356

Q36166728-9C436EF1-78C5-4C57-A7EB-A4802CCB6168

P407

Q36166728-9305944E-DEFA-42F4-A069-A2CDB8622F25

P433

Q36166728-7AA36089-02F2-4951-9DAD-119BA3E6E7E3

P478

Q36166728-F2EC8E52-7C8F-4107-B795-5F3094779B40

P50

Q36166728-D6501826-6B09-4C33-B601-6A93A4F1EB3C

P577

Q36166728-E29DCC29-0E4C-4400-BAE0-86443F10A8DA

P5875

Q36166728-40523B0A-975A-4343-8D49-7AE303F6B379

P698

Q36166728-89A21B52-8D62-4EA5-9BD8-3AC29581C968

P932

Q36166728-5B6F16EE-01D0-4057-A449-FF976A41DD5A

P356

P1433

The EMBO Journal

P1476

Modulation of synaptic functio ...... nositides PI(3,5)P₂ and PI(5)P

@en

P2093

Amber J McCartney

http://www.w3.org/2001/XMLSchema#string

Cole J Ferguson

http://www.w3.org/2001/XMLSchema#string

Lois S Weisman

http://www.w3.org/2001/XMLSchema#string

Michael A Sutton

http://www.w3.org/2001/XMLSchema#string

Miriam H Meisler

http://www.w3.org/2001/XMLSchema#string

Sergey N Zolov

http://www.w3.org/2001/XMLSchema#string

P2860

PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.

Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.

Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice

ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder

Regulation of postsynaptic AMPA responses by synaptojanin 1

Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology

P304

3442-3456

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/EMBOJ.2012.200

http://www.w3.org/2001/XMLSchema#string

P407

P433

16

http://www.w3.org/2001/XMLSchema#string

P478

31

http://www.w3.org/2001/XMLSchema#string

P50

P577

2012-07-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

230582179

http://www.w3.org/2001/XMLSchema#string

P698

22842785

http://www.w3.org/2001/XMLSchema#string

P932

3419932

http://www.w3.org/2001/XMLSchema#string