Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone - Wikidata - thesis-toulmin - TriplyDB

Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone

Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone

http://www.wikidata.org/entity/Q36186261

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The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis.Knockin of Cre Gene at Ins2 Locus Reveals No Cre Activity in Mouse Hypothalamic Neurons.The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2 Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male.Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.Long-term activation of PKA in β-cells provides sustained improvement to glucose control, insulin sensitivity and body weight Unexpected effects of the MIP-CreER transgene and tamoxifen on β-cell growth in C57Bl6/J male mice.Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion.Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation.LDB1 Regulates Energy Homeostasis During Diet-Induced Obesity.β-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response.Deletion of Protein Kinase D1 in Pancreatic Beta Cells Impairs Insulin Secretion in High-Fat Fed Mice.Considerations and guidelines for mouse metabolic phenotyping in diabetes research.A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice.Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice.β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation.Genetic Disruption of Adenosine Kinase in Mouse Pancreatic β-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance.Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice.SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.β Cell GLP-1R Signaling Alters α Cell Proglucagon Processing after Vertical Sleeve Gastrectomy in Mice.Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes

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Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone

http://www.wikidata.org/entity/Q36186261

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Clemence Meunier

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Daniel J Drucker

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Daniel Oropeza

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Harpreet K Brar

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Jonathan E Campbell

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Joshua C Neuman

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Julie Lacombe

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Khalil Bouyakdan

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Lionel Budry

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Mathieu Ferron

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P2860

Pancreas-specific Cre driver lines and considerations for their prudent use

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

Serotonin regulates mammary gland development via an autocrine-paracrine loop

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

A global double-fluorescent Cre reporter mouse

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Transgenic models of growth hormone action.

Characterization of mice expressing Ins1 gene promoter driven CreERT recombinase for conditional gene deletion in pancreatic β-cells.

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Thierry Alquier

Vincent Poitout

Jennifer L Estall

Rachel J Fenske

Gabrielle Perron

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2015-07-07T00:00:00Z

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26153246

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