Altered responsiveness to TGF-β results in reduced Papss2 expression and alterations in the biomechanical properties of mouse articular cartilage.
about
The Regulation of Steroid Action by Sulfation and DesulfationPAPSS2 promotes alkaline phosphates activity and mineralization of osteoblastic MC3T3-E1 cells by crosstalk and Smads signal pathways.Mutations in the latent TGF-beta binding protein 3 (LTBP3) gene cause brachyolmia with amelogenesis imperfecta.TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms.Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice.SOX9 protein is stabilized by TGF-β and regulates PAPSS2 mRNA expression in chondrocytes.Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin.
P2860
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P2860
Altered responsiveness to TGF-β results in reduced Papss2 expression and alterations in the biomechanical properties of mouse articular cartilage.
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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name
Altered responsiveness to TGF- ...... of mouse articular cartilage.
@ast
Altered responsiveness to TGF- ...... of mouse articular cartilage.
@en
type
label
Altered responsiveness to TGF- ...... of mouse articular cartilage.
@ast
Altered responsiveness to TGF- ...... of mouse articular cartilage.
@en
prefLabel
Altered responsiveness to TGF- ...... of mouse articular cartilage.
@ast
Altered responsiveness to TGF- ...... of mouse articular cartilage.
@en
P2093
P2860
P356
P1476
Altered responsiveness to TGF- ...... of mouse articular cartilage.
@en
P2093
Alan Eberhardt
Girish Ramaswamy
Philip Sohn
Rosa Serra
P2860
P2888
P356
10.1186/AR3762
P577
2012-03-06T00:00:00Z
P5875
P6179
1050851425