about
The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylasesEnzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promotersInterphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosisHistone H4 lysine 16 acetylation regulates cellular lifespanNuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?Is physical activity able to modify oxidative damage in cardiovascular aging?In Bacillus subtilis, the sirtuin protein deacetylase, encoded by the srtN gene (formerly yhdZ), and functions encoded by the acuABC genes control the activity of acetyl coenzyme A synthetaseSIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophagesA potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.Use of transcriptional synergy to augment sensitivity of a splicing reporter assayAsiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.Respected Sir(2): magic target for diabetesSirtuin-mediated nuclear differentiation and programmed degradation in TetrahymenaSuppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease.Visfatin as a novel mediator released by inflamed human endothelial cells.Neuroprotective effects of resveratrol on damages of mouse cortical neurons induced by β-amyloid through activation of SIRT1/Akt1 pathway.Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studiesBreaking an epigenetic chromatin switch: curious features of hysteresis in Saccharomyces cerevisiae telomeric silencing.Regulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase.Nutrition, sirtuins and aging.Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease.SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells.Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of NamptEffects of Low Concentrations of Rotenone upon Mitohormesis in SH-SY5Y Cells.Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing.Mechanisms and molecular probes of sirtuins.Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.Adrenergic signaling and oxidative stress: a role for sirtuins?Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.Functional complementation of sir2Δ yeast mutation by the human orthologous gene SIRT1.SIRT1 genetic variation is related to BMI and risk of obesity.SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functionsThe effect of Ramadan fasting on sirtuin and visfatin levels.Dietary restriction and brain health.Sirtuin mechanism and inhibition: explored with N(ε)-acetyl-lysine analogs.Catalysis and mechanistic insights into sirtuin activation.Erratum to: resveratrol and red wine, healthy heart and longevity.Histone deacetylases and their functions in plants.Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Small molecule regulation of Sir2 protein deacetylases.
@ast
Small molecule regulation of Sir2 protein deacetylases.
@en
type
label
Small molecule regulation of Sir2 protein deacetylases.
@ast
Small molecule regulation of Sir2 protein deacetylases.
@en
prefLabel
Small molecule regulation of Sir2 protein deacetylases.
@ast
Small molecule regulation of Sir2 protein deacetylases.
@en
P2093
P2860
P1433
P1476
Small molecule regulation of Sir2 protein deacetylases.
@en
P2093
Brian C Smith
John M Denu
Olivera Grubisha
P2860
P304
P356
10.1111/J.1742-4658.2005.04862.X
P407
P577
2005-09-01T00:00:00Z