Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport. - Wikidata - thesis-toulmin - TriplyDB

Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport.

Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport.

http://www.wikidata.org/entity/Q36265658

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Localization and functional characterization of the rat Oatp4c1 transporter in an in vitro cell system and rat tissues Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines Genetic variation in drug transporters in ethnic populations.Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates.The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy.Nuclear receptors CAR and PXR in the regulation of hepatic metabolism.SLCO1B1 521T-->C functional genetic polymorphism and lipid-lowering efficacy of multiple-dose pravastatin in Chinese coronary heart disease patients Human Organic Solute Transporter (hOST): protein interaction and membrane sorting process.Membrane transporter proteins: a challenge for CNS drug development.Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans.Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions.Transporter-mediated drug interactions: clinical implications and in vitro assessment.Influence of overexpression of efflux proteins on the function and gene expression of endogenous peptide transporters in MDR-transfected MDCKII cell lines.Kinetic determinants of hepatic clearance: plasma protein binding and hepatic uptake.Transporter-mediated uptake into cellular compartments.Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption.Simulations of the nonlinear dose dependence for substrates of influx and efflux transporters in the human intestine Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid.Dynamic localization of hepatocellular transporters in health and disease.Cultured mammary epithelial monolayers (BME-UV) express functional organic anion and cation transporters.New strategies to deliver anticancer drugs to brain tumors.Impact of cholesterol on ABC and SLC transporters expression and function and its role in disposition variability to lipid-lowering drugs.Which drug or drug delivery system can change clinical practice for brain tumor therapy?Cell-penetrating Peptide-mediated therapeutic molecule delivery into the central nervous system.Physiological and molecular biochemical mechanisms of bile formation.Genetic and/or non-genetic causes for inter-individual and inter-cellular variability in transporter protein expression: implications for understanding drug efficacy and toxicity.Noninvasive Assessment of Elimination and Retention using CT-FMT and Kinetic Whole-body Modeling.Causes and Consequences of Variability in Drug Transporter Activity in Pediatric Drug Therapy.Pharmacokinetic Drug Interactions with Panax ginseng.The expression of efflux and uptake transporters are regulated by statins in Caco-2 and HepG2 cells.Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP.Quantitative Evaluation of Drug Resistance Profile of Cells Expressing Wild-Type or Genetic Polymorphic Variants of the Human ABC Transporter ABCC4.Long-term effects of Panax ginseng on disposition of fexofenadine in rats in vivo.Distribution dynamics and functional importance of NHERF1 in regulation of Mrp-2 trafficking in hepatocytes.Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors.Ezrin regulates the expression of Mrp2/Abcc2 and Mdr1/Abcb1 along the rat small intestinal tract.Fatty Acid Binding Proteins: Potential Chaperones of Cytosolic Drug Transport in the Enterocyte?

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P2860

Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport.

http://www.wikidata.org/entity/Q36265658

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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Apical/basolateral surface exp ...... e in vectorial drug transport.

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Apical/basolateral surface exp ...... e in vectorial drug transport.

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Pharmaceutical Research

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Hiroshi Suzuki

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Kousei Ito

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Toshiharu Horie

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Yuichi Sugiyama

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P2860

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA

Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats

Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats

Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine.

Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain.

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

Bile salt transporters: molecular characterization, function, and regulation.

Pharmacological approaches to correcting the ion transport defect in cystic fibrosis.

MRP6 (ABCC6) detection in normal human tissues and tumors.

Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney.

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1559-1577

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10.1007/S11095-005-6810-2

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10

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22

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