STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia.
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JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indicationsEarly lymphoid lesions: conceptual, diagnostic and clinical challengesLarge granular lymphocytosis during dasatinib therapyActivating KIRs in Chronic Lymphoproliferative Disorder of NK Cells: Protection from Viruses and Disease Induction?Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyondMethotrexate Is a JAK/STAT Pathway InhibitorLarge granular lymphocytic leukemia. Current diagnostic and therapeutic approaches and novel treatment options.Vitamin D decreases STAT phosphorylation and inflammatory cytokine output in T-LGL leukemia.Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia.Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.Emergence of a STAT3 mutated NK clone in LGL leukemia.The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia.Chronic natural killer lymphoproliferative disorders: characteristics of an international cohort of 70 patients.The pathogenesis and treatment of large granular lymphocyte leukemiaThe spectrum of chronic CD8+ T-cell expansions: clinical features in 14 patients.Metronomic regimen as an effective treatment for aggressive T-LGL leukemia with central nervous system infiltration: clinical experience and review of literature.The challenging world of cytopenias: distinguishing myelodysplastic syndromes from other disorders of marrow failureSTAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients.Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3.Detection of monoclonal T populations in patients with KIR-restricted chronic lymphoproliferative disorder of NK cells.A targeted mutational landscape of angioimmunoblastic T-cell lymphoma.A novel missense (M206K) STAT3 mutation in diffuse large B cell lymphoma deregulates STAT3 signalingSTAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemiaFibrosis and subsequent cytopenias are associated with basic fibroblast growth factor-deficient pluripotent mesenchymal stromal cells in large granular lymphocyte leukemia.Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma.The Ying and Yang of STAT3 in Human DiseasePrimary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis.Alemtuzumab in T-cell large granular lymphocytic leukaemia: interim results from a single-arm, open-label, phase 2 studyPhenotypic profile of expanded NK cells in chronic lymphoproliferative disorders: a surrogate marker for NK-cell clonality.Signal transducer and activator of transcription 3: a year in review.Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.The 2016 revision of the World Health Organization classification of lymphoid neoplasms.Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia.Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations.STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.Indolent T-cell lymphoproliferative disease of the gastrointestinal tract.Mutations in the JAK/STAT and RAS signaling pathways are common in intestinal T-cell lymphomasDeep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes.Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation.Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRαβ(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL
P2860
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P2860
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
STAT3 mutations unify the path ...... granular lymphocyte leukemia.
@ast
STAT3 mutations unify the path ...... granular lymphocyte leukemia.
@en
type
label
STAT3 mutations unify the path ...... granular lymphocyte leukemia.
@ast
STAT3 mutations unify the path ...... granular lymphocyte leukemia.
@en
prefLabel
STAT3 mutations unify the path ...... granular lymphocyte leukemia.
@ast
STAT3 mutations unify the path ...... granular lymphocyte leukemia.
@en
P2093
P2860
P50
P921
P1433
P1476
STAT3 mutations unify the path ...... granular lymphocyte leukemia.
@en
P2093
Andres Jerez
Bartlomiej Przychodzen
Eric D Hsi
Francis Leblanc
Hanna Koskela
Hideki Makishima
Ines Gomez-Segui
Jaroslaw P Maciejewski
Kathryn Guinta
P2860
P304
P356
10.1182/BLOOD-2012-06-435297
P407
P577
2012-08-02T00:00:00Z