Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes
about
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptorGrowth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic functionThe structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinaseInteraction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-24PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient miceThe adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblastsA casein kinase I activity is constitutively associated with Nck.Role of IRS-1-GRB-2 complexes in insulin signaling.IGF1R signaling in Ewing sarcoma is shaped by clathrin-/caveolin-dependent endocytosis.Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells.Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase.Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3.Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation.Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells.Enhancement or inhibition of insulin signaling by insulin receptor substrate 1 is cell context dependent.Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase.A novel, rapid, inhibitory effect of insulin on alpha1beta2gamma2s gamma-aminobutyric acid type A receptors.Growth hormone, insulin-like growth factors, and the skeleton.Differential signaling to glycogen synthesis by the intracellular domain of the insulin versus the insulin-like growth factor-1 receptor. Evidence from studies of TrkC-chimeras.Localization of sequences for the basal and insulin-like growth factor-I inducible activity of the fatty acid synthase promoter in 3T3-L1 fibroblasts.Insulin and insulin-like growth factor I (IGF-I) stimulate GLUT4 glucose transporter translocation in Xenopus oocytesMutant of insulin receptor substrate-1 incapable of activating phosphatidylinositol 3-kinase did not mediate insulin-stimulated maturation of Xenopus laevis oocytes.Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner.Increased insulin receptor substrate-1 and enhanced skeletal muscle insulin sensitivity in mice lacking CCAAT/enhancer-binding protein beta.Xenopus laevis insulin receptor substrate IRS-1 is important for eye development.Insulin-like growth factors and their binding proteins: Potential relevance to reproductive physiology.
P2860
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P2860
Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Insulin receptor substrate 1 m ...... maturation of Xenopus oocytes
@ast
Insulin receptor substrate 1 m ...... maturation of Xenopus oocytes
@en
type
label
Insulin receptor substrate 1 m ...... maturation of Xenopus oocytes
@ast
Insulin receptor substrate 1 m ...... maturation of Xenopus oocytes
@en
prefLabel
Insulin receptor substrate 1 m ...... maturation of Xenopus oocytes
@ast
Insulin receptor substrate 1 m ...... maturation of Xenopus oocytes
@en
P2093
P2860
P356
P1476
Insulin receptor substrate 1 m ...... maturation of Xenopus oocytes
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.11.5172
P407
P577
1993-06-01T00:00:00Z