Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation. - Wikidata - thesis-toulmin - TriplyDB

Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.

Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.

http://www.wikidata.org/entity/Q36371357

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Adult neurogenesis in the mammalian brain: significant answers and significant questions Alzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms Chemokine receptor CXCR2: physiology regulator and neuroinflammation controller?The role of microglia in adult hippocampal neurogenesis APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation Presenilin-1 familial Alzheimer's disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice.Minimal NF-κB activity in neurons Neurodegenerative disease and adult neurogenesis The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation Overstimulation of newborn mice leads to behavioral differences and deficits in cognitive performance Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.CCL2 affects β-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer's disease.Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF.Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice.Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling.Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease Presenilin/gamma-Secretase and Inflammation.ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.Adult hippocampal neurogenesis and its role in Alzheimer's disease When neurogenesis encounters aging and disease Microglia: unique and common features with other tissue macrophages.Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse.Minocycline treatment ameliorates interferon-alpha- induced neurogenic defects and depression-like behaviors in mice.Moderate fetal alcohol exposure impairs neurogenic capacity of murine neural stem cells isolated from the adult subventricular zone Therapeutic application of neural stem cells and adult neurogenesis for neurodegenerative disorders: regeneration and beyond Transcription factor p53 influences microglial activation phenotype Netrin-5 is highly expressed in neurogenic regions of the adult brain.The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain.The effects of MyD88 deficiency on exploratory activity, anxiety, motor coordination, and spatial learning in C57BL/6 and APPswe/PS1dE9 mice.Exercise and early-onset Alzheimer's disease: theoretical considerations.HIV-1 Tat-induced microglial activation and neuronal damage is inhibited via CD45 modulation: A potential new treatment target for HAND.Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair.The Ever-Changing Morphology of Hippocampal Granule Neurons in Physiology and Pathology Presenilin transgenic mice as models of Alzheimer's disease.Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells.Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.Does microglial dysfunction play a role in autism and Rett syndrome?

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P2860

Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.

http://www.wikidata.org/entity/Q36371357

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Karthikeyan Veeraraghavalu

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Orly Lazarov

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Richard M Ransohoff

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P2860

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces

Skeletal and CNS defects in Presenilin-1-deficient mice

The adult mouse hippocampal progenitor is neurogenic but not a stem cell

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells

Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal.

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