Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
about
In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies.A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levelsSeparate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient miceA sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.Lyn kinase promotes erythroblast expansion and late-stage development.Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels.Akt-dependent cytokine production in mast cells.Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone.Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxisModulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice.Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia.The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling.Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased cell proliferation.BTK Signaling in B Cell Differentiation and Autoimmunity.The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis.Synergistic B cell activation by CD40 and the B cell antigen receptor: role of B lymphocyte antigen receptor-mediated kinase activation and tumor necrosis factor receptor-associated factor regulation.Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling.Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.CD11c expression identifies a population of extrafollicular antigen-specific splenic plasmablasts responsible for CD4 T-independent antibody responses during intracellular bacterial infection.Btk regulates multiple stages in the development and survival of B-1 cells.The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: rescue by over-expression of Bcl-2.Bruton's Tyrosine Kinase Deficiency Inhibits Autoimmune Arthritis in Mice but Fails to Block Immune Complex-Mediated Inflammatory Arthritis.Bruton's Tyrosine Kinase, a Component of B Cell Signaling Pathways, Has Multiple Roles in the Pathogenesis of Lupus.Increased expression of Bruton's tyrosine kinase in peripheral blood is associated with lupus nephritis.
P2860
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P2860
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
@ast
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
@en
type
label
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
@ast
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
@en
prefLabel
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
@ast
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
@en
P2093
P2860
P356
P1476
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
@en
P2093
P2860
P304
P356
10.1084/JEM.188.5.833
P407
P577
1998-09-01T00:00:00Z