Protons block BK channels by competitive inhibition with K+ and contribute to the limits of unitary currents at high voltages.
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BK channels: multiple sensors, one activation gateFunction and regulation of large conductance Ca(2+)-activated K+ channel in vascular smooth muscle cellsPhilosophy of voltage-gated proton channelsLow resistance, large dimension entrance to the inner cavity of BK channels determined by changing side-chain volume.Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating.What keeps Kv channels small? The molecular physiology of modesty.Proton block of proton-activated TRPV1 current.Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics.The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channelsProbing the geometry of the inner vestibule of BK channels with sugars.Lack of negative slope in I-V plots for BK channels at positive potentials in the absence of intracellular blockers.Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.Proton inhibition of unitary currents of vanilloid receptors.Targeting BK (big potassium) channels in epilepsy.Intracellular BK(Ca) (iBK(Ca)) channels.Involvement of tumor acidification in brain cancer pathophysiology.BKCa channel dysfunction in neurological diseasesMolecular Determinants of BK Channel Functional Diversity and Functioning.Low pHo boosts burst firing and catecholamine release by blocking TASK-1 and BK channels while preserving Cav1 channels in mouse chromaffin cells.Ca2+ block and flickering both contribute to the negative slope of the IV curve in BK channelsUnique inner pore properties of BK channels revealed by quaternary ammonium block.Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain.Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels
P2860
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P2860
Protons block BK channels by competitive inhibition with K+ and contribute to the limits of unitary currents at high voltages.
description
2004 nî lūn-bûn
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name
Protons block BK channels by c ...... ary currents at high voltages.
@ast
Protons block BK channels by c ...... ary currents at high voltages.
@en
type
label
Protons block BK channels by c ...... ary currents at high voltages.
@ast
Protons block BK channels by c ...... ary currents at high voltages.
@en
prefLabel
Protons block BK channels by c ...... ary currents at high voltages.
@ast
Protons block BK channels by c ...... ary currents at high voltages.
@en
P2860
P356
P1476
Protons block BK channels by c ...... ary currents at high voltages.
@en
P2093
Karl L Magleby
Tinatin I Brelidze
P2860
P304
P356
10.1085/JGP.200308951
P577
2004-03-01T00:00:00Z