Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks

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R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation Reactivity and Cross-Linking of 5'-Terminal Abasic Sites within DNA.

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Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks

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2015 nî lūn-bûn

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Gastric cancer associated vari ...... ssociated double strand breaks

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Gastric cancer associated vari ...... ssociated double strand breaks

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Gastric cancer associated vari ...... ssociated double strand breaks

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Gastric cancer associated vari ...... ssociated double strand breaks

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Gastric cancer associated vari ...... ssociated double strand breaks

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Gastric cancer associated vari ...... ssociated double strand breaks

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Gastric cancer associated vari ...... ssociated double strand breaks

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Antoni A Nemec

http://www.w3.org/2001/XMLSchema#string

Dawit Kidane

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Jenna Rozacky

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Joann B Sweasy

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Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes

Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway

Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase beta and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity

The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells

Unfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s Pathway

Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Is there a link between DNA polymerase beta and cancer?

Characterization of homologous recombination induced by replication inhibition in mammalian cells

Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA

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24474-24487

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scholarly article

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10.18632/ONCOTARGET.4426

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English

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2015-06-10T00:00:00Z

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278788442

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26090616

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4695199

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Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks

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P2860

P2860

Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P5875

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P5875

P698

P932