Cytochrome P450s and other enzymes in drug metabolism and toxicity.
about
Toxic hepatitis in occupational exposure to solventsCYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysisArachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevanceRegulation of Drosophila metamorphosis by xenobiotic response regulatorsSystematic identification and evolutionary analysis of catalytically versatile cytochrome p450 monooxygenase families enriched in model basidiomycete fungiThe Role of Protein-Protein and Protein-Membrane Interactions on P450 FunctionComplexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITYPatient counseling about herbal-drug interactions.Cytochrome P450 site of metabolism prediction from 2D topological fingerprints using GPU accelerated probabilistic classifiersInsights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculationsP450 monooxygenases (P450ome) of the model white rot fungus Phanerochaete chrysosporiumMultiple roles of Nrf2-Keap1 signaling: regulation of development and xenobiotic response using distinct mechanismsLinear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability EstimationMetabolic enzyme microarray coupled with miniaturized cell-culture array technology for high-throughput toxicity screeningAflatoxin B1 metabolismRS-Predictor models augmented with SMARTCyp reactivities: robust metabolic regioselectivity predictions for nine CYP isozymes.A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data.Extending P450 site-of-metabolism models with region-resolution data.Novel Uses of In Vitro Data to Develop Quantitative Biological Activity Relationship Models for in Vivo Carcinogenicity Prediction.CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells.CYP2C9-CYP3A4 protein-protein interactions: role of the hydrophobic N terminus.Regulation of human CYP2C9 expression by electrophilic stress involves activator protein 1 activation and DNA looping.Computational and in vitro studies on the inhibitory effects of herbal compounds on human cytochrome P450 1A2.High-throughput and combinatorial gene expression on a chip for metabolism-induced toxicology screening.Multiple-approaches to the identification and quantification of cytochromes P450 in human liver tissue by mass spectrometry.Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicityCharacterization of 107 genomic DNA reference materials for CYP2D6, CYP2C19, CYP2C9, VKORC1, and UGT1A1: a GeT-RM and Association for Molecular Pathology collaborative project.Evaluation of metabolism-mediated herb-drug interactions.Safety and tolerability of antiepileptic drug treatment in children with epilepsy.The Simplest Flowchart Stating the Mechanisms for Organic Xenobiotics-induced Toxicity: Can it Possibly be Accepted as a "Central Dogma" for Toxic Mechanisms?The pathway ontology - updates and applications.Cytochrome P450 single nucleotide polymorphisms in an indigenous Tanzanian population: a concern about the metabolism of artemisinin-based combinations.Synthetic studies of neoclerodane diterpenes from Salvia divinorum: role of the furan in affinity for opioid receptorsMetabolic pathways of the camptothecin analog AR-67Psychiatric treatment considerations with direct acting antivirals in hepatitis CWhichCyp: prediction of cytochromes P450 inhibition.Indolealkylamines: biotransformations and potential drug-drug interactionsActive-site residues move independently from the rest of the protein in a 200 ns molecular dynamics simulation of cytochrome P450 CYP119.Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its inductionMolecular mechanisms of the microsomal mixed function oxidases and biological and pathological implications
P2860
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P2860
Cytochrome P450s and other enzymes in drug metabolism and toxicity.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Cytochrome P450s and other enzymes in drug metabolism and toxicity.
@ast
Cytochrome P450s and other enzymes in drug metabolism and toxicity.
@en
type
label
Cytochrome P450s and other enzymes in drug metabolism and toxicity.
@ast
Cytochrome P450s and other enzymes in drug metabolism and toxicity.
@en
prefLabel
Cytochrome P450s and other enzymes in drug metabolism and toxicity.
@ast
Cytochrome P450s and other enzymes in drug metabolism and toxicity.
@en
P2860
P356
P1433
P1476
Cytochrome P450s and other enzymes in drug metabolism and toxicity.
@en
P2093
F Peter Guengerich
P2860
P2888
P304
P356
10.1208/AAPSJ080112
P407
P577
2006-03-10T00:00:00Z
P5875
P6179
1051190713