The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.
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Inward rectifiers and their regulation by endogenous polyaminesAn insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malariaIdentification of putative potassium channel homologues in pathogenic protozoaPharmacological inhibition of IK1 by PA-6 in isolated rat hearts affects ventricular repolarization and refractorinessHigh-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1.Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1.Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities.The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics.Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation.Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets.Structural bases for the different anti-fibrillatory effects of chloroquine and quinidine.Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicityComputational and functional analyses of a small-molecule binding site in ROMK.Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine K(IR)2.2 ion ChannelA novel frequency analysis method for assessing K(ir)2.1 and Na (v)1.5 currents.Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference.Molecular mechanisms of chloroquine inhibition of heterologously expressed Kir6.2/SUR2A channels.Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria.KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmiaNovel molecular targets for atrial fibrillation therapy.Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment of bacterial infections: a puzzling paradox or a logical consequence of their mode of action?Evaluation of Melissa officinalis (Lemon Balm) Effects on Heart Electrical SystemProtection against Shiga ToxinsInhibitors of intravesicular acidification protect against Shiga toxin in a pH-independent manner.Investigations into the correlation properties of membrane electroporation-induced inward currents: prediction of pore formation.Chloroquine blocks a mutant Kir2.1 channel responsible for short QT syndrome and normalizes repolarization properties in silico.ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium ChannelsOpening of the inward rectifier potassium channel alleviates maladaptive tissue repair following myocardial infarction.Voltage-dependent biphasic effects of chloroquine on delayed rectifier K(+)-channel currents in murine thymocytes.Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome.Inhibition of Kir4.1 potassium channels by quinacrine.Modelling the effects of chloroquine on KCNJ2-linked short QT syndrome.Chloroquine and diazepam for her last sleep.Flow- and voltage-dependent blocking effect of ethosuximide on the inward rectifier K⁺ (Kir2.1) channel.Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224.A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome.
P2860
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P2860
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.
@ast
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.
@en
type
label
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.
@ast
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.
@en
prefLabel
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.
@ast
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.
@en
P2093
P2860
P356
P1476
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.
@en
P2093
Jason Rupp
José A Sánchez-Chapula
Martin Tristani-Firouzi
Ricardo A Navarro-Polanco
Tania Ferrer-Villada
P2860
P304
P356
10.1073/PNAS.0708153105
P407
P577
2008-01-23T00:00:00Z