A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.
about
The footprint of genome architecture in the largest genome expansion in RNA virusesViral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide DepletionDevelopment of next-generation respiratory virus vaccines through targeted modifications to viral immunomodulatory genesCurrent advancements and potential strategies in the development of MERS-CoV vaccinesStructural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase.Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeuticsSequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in MosquitoesA decade after SARS: strategies for controlling emerging coronavirusesGain-of-Function Research and the Relevance to Clinical Practice.The emergence of the Middle East respiratory syndrome coronavirusRNA virus reverse genetics and vaccine design.Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection.Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelityMurine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.Coronaviruses: an overview of their replication and pathogenesis.RNA populations in immunocompromised patients as reservoirs for novel norovirus variantsCoronavirus non-structural protein 16: evasion, attenuation, and possible treatments.Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelityProtein-Protein Interactions of Viroporins in Coronaviruses and Paramyxoviruses: New Targets for Antivirals?Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complexCharacterization of a Pathogenic Full-Length cDNA Clone and Transmission Model for Porcine Epidemic Diarrhea Virus Strain PC22ALow-Fidelity Polymerases of Alphaviruses Recombine at Higher Rates To Overproduce Defective Interfering Particles.Emergence of a Large-Plaque Variant in Mice Infected with Coxsackievirus B3.Complete protection against severe acute respiratory syndrome coronavirus-mediated lethal respiratory disease in aged mice by immunization with a mouse-adapted virus lacking E protein.Mutagenesis of Coronavirus nsp14 Reveals Its Potential Role in Modulation of the Innate Immune Response.Middle East respiratory syndrome vaccines.Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple MutagensEngineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidateReverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus.Dynamic viral dissemination in mice infected with yellow fever virus strain 17D.Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activityAlphavirus mutator variants present host-specific defects and attenuation in mammalian and insect modelsAttenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity.Epigenetic Landscape during Coronavirus InfectionThe role of mutational robustness in RNA virus evolution.The high cost of fidelity.Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines.MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis.Channel-Inactivating Mutations and Their Revertant Mutants in the Envelope Protein of Infectious Bronchitis Virus.
P2860
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P2860
A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
A live, impaired-fidelity coro ...... mouse model of lethal disease.
@ast
A live, impaired-fidelity coro ...... mouse model of lethal disease.
@en
type
label
A live, impaired-fidelity coro ...... mouse model of lethal disease.
@ast
A live, impaired-fidelity coro ...... mouse model of lethal disease.
@en
prefLabel
A live, impaired-fidelity coro ...... mouse model of lethal disease.
@ast
A live, impaired-fidelity coro ...... mouse model of lethal disease.
@en
P2093
P2860
P356
P1433
P1476
A live, impaired-fidelity coro ...... mouse model of lethal disease.
@en
P2093
Lance D Eckerle
Meagan Bolles
Michelle M Becker
Rachel L Graham
P2860
P2888
P304
P356
10.1038/NM.2972
P407
P577
2012-11-11T00:00:00Z