LRRK2 inhibition attenuates microglial inflammatory responses
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GTP binding controls complex formation by the human ROCO protein MASL1Why is nitric oxide important for our brain?Neuroinflammation in Parkinson's disease and its potential as therapeutic targetInsights into Neuroinflammation in Parkinson's Disease: From Biomarkers to Anti-Inflammatory Based TherapiesOxidative stress and Parkinson's diseaseCurrent understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor designThe complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseaseThe role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's DiseaseTen years and counting: moving leucine-rich repeat kinase 2 inhibitors to the clinicThe role of the LRRK2 gene in ParkinsonismM1 and M2 immune activation in Parkinson's Disease: Foe and ally?Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasisMicroglia development and functionLRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.Parkinson's disease and immune system: is the culprit LRRKing in the periphery?Protective Microglia and Their Regulation in Parkinson's DiseaseInhibition of LRRK2 kinase activity stimulates macroautophagyA novel GTP-binding inhibitor, FX2149, attenuates LRRK2 toxicity in Parkinson's disease modelsmTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1Modelling idiopathic Parkinson disease as a complex illness can inform incidence rate in healthy adults: the PREDIGT scoreConditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegenerationLeucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1.LRRK2 levels in immune cells are increased in Parkinson's diseaseParkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodentsAbrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.Leucine-rich α2-glycoprotein is a novel biomarker of neurodegenerative disease in human cerebrospinal fluid and causes neurodegeneration in mouse cerebral cortexTSG (2,3,4' ,5-tetrahydroxystilbene 2-O-β-D-glucoside) suppresses induction of pro-inflammatory factors by attenuating the binding activity of nuclear factor-κB in microglia.Parkinson's disease: dopaminergic nerve cell model is consistent with experimental finding of increased extracellular transport of α-synuclein.Herb-Partitioned Moxibustion and the miRNAs Related to Crohn's Disease: A Study Based on Rat Models.Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disordersLeucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells
P2860
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P2860
LRRK2 inhibition attenuates microglial inflammatory responses
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
LRRK2 inhibition attenuates microglial inflammatory responses
@ast
LRRK2 inhibition attenuates microglial inflammatory responses
@en
type
label
LRRK2 inhibition attenuates microglial inflammatory responses
@ast
LRRK2 inhibition attenuates microglial inflammatory responses
@en
prefLabel
LRRK2 inhibition attenuates microglial inflammatory responses
@ast
LRRK2 inhibition attenuates microglial inflammatory responses
@en
P2093
P2860
P50
P1476
LRRK2 inhibition attenuates microglial inflammatory responses
@en
P2093
Nour Sukar
Philip J Webber
Tara M DeSilva
P2860
P304
P356
10.1523/JNEUROSCI.5601-11.2012
P407
P577
2012-02-01T00:00:00Z