NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.
about
Pharmacogenomics of human P450 oxidoreductaseVitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication.Prenatal Exposure to a Maternal High-Fat Diet Affects Histone Modification of Cardiometabolic Genes in Newborn Rats.Molecular mechanisms of the microsomal mixed function oxidases and biological and pathological implicationsIsolation and Expression Analysis of CYP9A11 and Cytochrome P450 Reductase Gene in the Beet Armyworm (Lepidoptera: Noctuidae).Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-pyrido[2,3-b]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice.Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence.Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine.Effects of major transporter and metabolizing enzyme gene polymorphisms on carbamazepine metabolism in Chinese patients with epilepsy.Altered CYP19A1 and CYP3A4 Activities Due to Mutations A115V, T142A, Q153R and P284L in the Human P450 Oxidoreductase.Redox-linked domain movements in the catalytic cycle of cytochrome p450 reductase.Drug-enhanced carbon monoxide production from heme by cytochrome P450 reductaseApplication of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function.Critical Role of Hepatic Cyp450s in the Testis-Specific Toxicity of (5R)-5-Hydroxytriptolide in C57BL/6 Mice.Cytochrome P450 expression in mouse brain: specific isoenzymes involved in Phase I metabolizing system of porphyrinogenic agents in both microsomes and mitochondria.siRNA-mediated knockdown of P450 oxidoreductase in rats: a tool to reduce metabolism by CYPs and increase exposure of high clearance compounds.CYP2D6 protein level is the major contributor to inter-individual variability in CYP2D6-mediated drug metabolism in healthy human liver tissue.Properties of purified CYP2R1 in a reconstituted membrane environment and its 25-hydroxylation of 20-hydroxyvitamin D3.Altered hepatic drug-metabolizing activity in rats suffering from hypoxemia with experimentally induced acute lung impairment.Spatiotemporal Compartmentalization of Hepatic NADH and NADPH metabolism.Solution structure of the cytochrome P450 reductase-cytochrome c complex determined by neutron scattering.POR*28 SNP is associated with lipid response to atorvastatin in children and adolescents with familial hypercholesterolemia.Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency.Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase
P2860
Q26998463-592248EE-EF2E-4E0F-AD12-931739EAB822Q27303349-78326282-230F-4BF2-93F9-DDD38024EF4AQ33616987-C6B6052F-D6E8-4A4E-8E8D-8A5D78DE60FBQ35024501-DBD17625-D8FF-420D-8A2D-7AA1DB9BEFA6Q36353293-312DB351-1282-476D-90D1-53ADCF34064DQ36435702-67EC4284-467F-4879-AA3A-545C9F4B7BDFQ37415654-959E6571-81CB-44F0-9A54-7054C4E092FCQ38753508-CDF4EF79-B5F2-4053-931A-2D9C146BEDA4Q40062685-34A59424-15C2-4438-A3D5-CA7321C0D555Q41704645-A41B7CEF-1333-486A-8C8C-8E76E2229C3CQ41808460-84FEA445-A9BD-447C-B85E-C9809C331465Q41808959-78877242-81E5-4D35-AB29-20A5B2DD89D3Q42290726-E4B8E53F-3E13-4B19-AF64-2E5FC49E50D2Q43779543-2E64B60F-CC29-4746-B106-7D3B354A7ED2Q47096419-77BE05B0-98DC-4907-8833-1657844579A8Q47162329-BE7DA433-36BC-421F-A4B2-0B0CF96B87F3Q47791484-6131F551-1881-4E1E-9E35-D9D57E76CBF9Q47849903-87B2F9DD-2E73-49C8-A531-A1A9089B1045Q49933391-9C2B1B77-C93A-44F8-8B9B-61473D3718E4Q50885385-2440425A-5AE0-4EB2-927F-221FDC3569E5Q50915138-41DFDE3B-AFBC-4825-A29E-EC267FA1020FQ51245810-5B5EBF37-F9F3-42DC-BDF1-E5675C093FF9Q52373725-54B3AA80-D551-4625-AC79-861B86A0A65AQ53665083-993FEB07-A166-46EB-990A-A23FDC9019F7Q55638445-0234EF60-38D5-419B-90AF-D723E61F8248Q57975758-492227EF-B675-4595-8484-3BB4432CC356
P2860
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.
@ast
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.
@en
type
label
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.
@ast
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.
@en
prefLabel
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.
@ast
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.
@en
P2093
P2860
P50
P356
P1476
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology
@en
P2093
Christa E Flück
David S Riddick
Lesley A McLaughlin
Qing-Yu Zhang
Robert D Finn
Sebastien Ronseaux
Todd D Porter
Xinxin Ding
P2860
P356
10.1124/DMD.112.048991
P577
2012-10-19T00:00:00Z