Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling - Wikidata - thesis-toulmin - TriplyDB

Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling

Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling

http://www.wikidata.org/entity/Q36556068

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Elevated Lifetime Lead Exposure Impedes Osteoclast Activity and Produces an Increase in Bone Mass in Adolescent Mice Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice.Overconstrained library-based fitting method reveals age- and disease-related differences in transcutaneous Raman spectra of murine bones Inhibition of beta-catenin signaling by Pb leads to incomplete fracture healing Fibulin-1 is required for bone formation and Bmp-2-mediated induction of Osterix.Structurally-diverse, PPARγ-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells.The convergence of fracture repair and stem cells: interplay of genes, aging, environmental factors and disease.Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/β-CATENIN SIGNALING PATHWAY.Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells Allogeneic and Autogenous Bone Grafts Are Affected by Historical Donor Environmental Exposure.Tungsten Promotes Sex-Specific Adipogenesis in the Bone by Altering Differentiation of Bone Marrow-Resident Mesenchymal Stromal Cells.Bone lead (Pb) content at the tibia is associated with thinner distal tibia cortices and lower volumetric bone density in postmenopausal women.Environmental Factors Impacting Bone-Relevant Chemokines.Reduced bone and body mass in young male rats exposed to lead.More fat, less bone? Flame retardant may deliver a one-two punch.A One-Two Punch to Bone: Assessing the Combined Impact of Lead and a High-Fat Diet.Blood Lead, Bone Turnover, and Survival in Amyotrophic Lateral Sclerosis.Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue.Nuclear receptor and VEGF pathways for gene-blood lead interactions, on bone mineral density, in Korean smokers.Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study.Spatially offset Raman spectroscopy for bone strength prediction

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P2860

Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling

http://www.wikidata.org/entity/Q36556068

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2012 nî lūn-bûn

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Heavy metal lead exposure, ost ...... nd depression of Wnt signaling

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Heavy metal lead exposure, ost ...... nd depression of Wnt signaling

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Environmental Health Perspectives

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Heavy metal lead exposure, ost ...... nd depression of Wnt signaling

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Andrew J Berger

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Deborah A Cory-Slechta

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Eric E Beier

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J Edward Puzas

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Jason R Maher

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Tzong-Jen Sheu

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P2860

Inhibition of adipogenesis by Wnt signaling

Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13)

Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling

Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency.

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

Lead inhibits secretion of osteonectin/SPARC without significantly altering collagen or Hsp47 production in osteoblast-like ROS 17/2.8 cells

Enhanced learning deficits in female rats following lifetime pb exposure combined with prenatal stress.

Playing with bone and fat.

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97-104

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10.1289/EHP.1205374

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1

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121

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Micheal J Zuscik

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2012-10-19T00:00:00Z

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232534065

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3552813

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