IkappaB kinase is an essential component of the Tpl2 signaling pathway. - Wikidata - thesis-toulmin - TriplyDB

IkappaB kinase is an essential component of the Tpl2 signaling pathway.

IkappaB kinase is an essential component of the Tpl2 signaling pathway.

http://www.wikidata.org/entity/Q36732464

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Regulation of miRNA transcription in macrophages in response to Candida albicans The tyrosine kinase Syk regulates TPL2 activation signals Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase Ubiquitin signaling in immune responses NF-κB, the first quarter-century: remarkable progress and outstanding questions The TLR and IL-1 signalling network at a glance Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer IKK mediates ischemia-induced neuronal death Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha.IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor.TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling.IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.TLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase.Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation The IκB kinase complex in NF-κB regulation and beyond.Dendritic cells from humans with hypomorphic mutations in IKBKG/NEMO have impaired mitogen-activated protein kinase activity.The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.Toll-like receptor 2-dependent extracellular signal-regulated kinase signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells IKK biology.p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms.Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses.Inflammation-activated protein kinases as targets for drug development Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400 A comprehensive map of the toll-like receptor signaling network.ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB.Coordinating TLR-activated signaling pathways in cells of the immune system.The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.Advances in targeting IKK and IKK-related kinases for cancer therapy Ebola virus VP35 induces high-level production of recombinant TPL-2-ABIN-2-NF-κB1 p105 complex in co-transfected HEK-293 cells Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.

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IkappaB kinase is an essential component of the Tpl2 signaling pathway.

http://www.wikidata.org/entity/Q36732464

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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name

IkappaB kinase is an essential component of the Tpl2 signaling pathway.

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IkappaB kinase is an essential component of the Tpl2 signaling pathway.

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type

label

IkappaB kinase is an essential component of the Tpl2 signaling pathway.

@ast

IkappaB kinase is an essential component of the Tpl2 signaling pathway.

@en

prefLabel

IkappaB kinase is an essential component of the Tpl2 signaling pathway.

@ast

IkappaB kinase is an essential component of the Tpl2 signaling pathway.

@en

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P356

MCB.24.13.6040-6048.2004

P1433

Molecular and Cellular Biology

P1476

IkappaB kinase is an essential component of the Tpl2 signaling pathway.

@en

P2093

Michael Waterfield

http://www.w3.org/2001/XMLSchema#string

Minying Zhang

http://www.w3.org/2001/XMLSchema#string

Shao-Cong Sun

http://www.w3.org/2001/XMLSchema#string

Wei Jin

http://www.w3.org/2001/XMLSchema#string

William Reiley

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P2860

NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

The NF-kappa B and I kappa B proteins: new discoveries and insights

NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha

SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

Toll-like receptors in the induction of the innate immune response

NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

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6040-6048

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scholarly article

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10.1128/MCB.24.13.6040-6048.2004

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15199157

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480897

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