Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins.
about
Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthaseStructure and Function of an NADPH-Cytochrome P450 Oxidoreductase in an Open Conformation Capable of Reducing Cytochrome P450A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanismArchitecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domainIntraprotein electron transfer in inducible nitric oxide synthase holoenzymeRegulation of interdomain electron transfer in the NOS output state for NO productionPulsed EPR determination of the distance between heme iron and FMN centers in a human inducible nitric oxide synthase.Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transferElectron transfer in a human inducible nitric oxide synthase oxygenase/FMN construct co-expressed with the N-terminal globular domain of calmodulinStructural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain.Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthaseEffect of solution viscosity on intraprotein electron transfer between the FMN and heme domains in inducible nitric oxide synthaseSurface charges and regulation of FMN to heme electron transfer in nitric-oxide synthase.Comparing the temperature dependence of FMN to heme electron transfer in full length and truncated inducible nitric oxide synthase proteinsMolecular architecture of mammalian nitric oxide synthases.Mechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions.Lobe-specific calcium binding in calmodulin regulates endothelial nitric oxide synthase activation.Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles.Regulatory role of Glu546 in flavin mononucleotide-heme electron transfer in human inducible nitric oxide synthase.A kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual-flavin enzyme-simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains.Single-molecule spectroscopy reveals how calmodulin activates NO synthase by controlling its conformational fluctuation dynamics.Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains.Insight into structural rearrangements and interdomain interactions related to electron transfer between flavin mononucleotide and heme in nitric oxide synthase: A molecular dynamics studyRole of an isoform-specific serine residue in FMN-heme electron transfer in inducible nitric oxide synthase.Thermodynamic characterization of five key kinetic parameters that define neuronal nitric oxide synthase catalysis.Neutralizing a surface charge on the FMN subdomain increases the activity of neuronal nitric-oxide synthase by enhancing the oxygen reactivity of the enzyme heme-nitric oxide complexDissecting regulation mechanism of the FMN to heme interdomain electron transfer in nitric oxide synthases.Mutations in the FMN domain modulate MCD spectra of the heme site in the oxygenase domain of inducible nitric oxide synthase.Charge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase.Gaseous neurotransmitters and their role in anapyrexia.Research progress on neurobiology of neuronal nitric oxide synthase.Dynamic control of electron transfers in diflavin reductases.Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.Phosphorylation Controls Endothelial Nitric-oxide Synthase by Regulating Its Conformational Dynamics.A Cross-Domain Charge Interaction Governs the Activity of NO Synthase.
P2860
Q24655182-BE89D86F-6892-48F7-9CBE-41B3B4422424Q27653521-532C5A4E-E397-4AE9-A9C7-05B0F497A036Q28576068-19CD94ED-30E5-4CBB-B75E-2946DF671A17Q30580764-A6E6D01A-6855-4FBA-B985-0DB7B77D4F91Q33373365-15A6E35C-D37F-4D25-A7C4-6BAA4457040AQ33494841-8D1CE288-6BD0-44F7-9920-025F04B3831FQ33652757-1B3B8CE5-64D7-4153-84C8-75E2B7089BFDQ33661383-BD0C6ADD-C5DD-471E-B3EE-46D672394F3DQ33702908-5C7A46F8-7DA3-428A-B6E1-5083BC748139Q33830350-FC1D304D-7DD4-4E52-84B4-9DAFED2297E7Q33923728-55D72EEB-105A-4B87-8B8C-CF78CAD53161Q33976082-708DD8F9-9C53-43CF-BDA6-61078488BD6BQ34094541-85BC1CC8-0328-4D67-82F0-59235E8CA5F6Q34111866-FCC5AFF2-26AE-4217-AEF0-4293987061AAQ34144575-9362FD5E-D8A7-46DA-A32B-203F7A7539C1Q34241528-5AA24C00-50E1-40FC-856B-4D1BCA5D9A6AQ34328328-EC7FA516-D054-4563-A34C-DD85D7663519Q34577168-B6B75DEF-AAC1-417E-AE53-2167FB1369D5Q34660741-9C102EC2-2A0F-4157-9492-9C444FA24331Q35434947-901FC214-D7D4-4694-8C51-7C5AF657F0ADQ36103003-09196862-5C42-4C87-B15B-E1E5212F588FQ36216296-ECC525E0-0C8D-48AF-B4C6-4A8F2DFDDD32Q36403178-9D8B6AA3-36DE-45B2-9E9E-111BA3C96411Q36479661-01CABF01-657C-40FD-927D-FFA4F148C50BQ37156500-40DAA27F-0762-4D5A-902E-461C160E0812Q37339263-098E2C2F-C7F6-4E88-9829-F063E7AB4910Q37350981-9573BE07-06EA-4692-A7E9-1843817B7BF5Q37368047-B86482D0-B7DC-4E63-9DDA-5254239715D4Q37438886-37954613-056A-4E82-B560-B62DC638E30CQ37761990-355C5A45-A140-4F26-AA44-2E100A87A70AQ37832652-D29FCD22-9909-4694-94B8-EC08DDEA45C2Q38064332-FF01C8F4-684F-464F-8321-CE844D9B4E3EQ41897409-B6A1B674-2373-4D40-B407-1581B323625DQ42725750-D7DAB598-A696-4DE6-885E-BA5BE8582748Q50134156-13417F26-99B2-420E-A555-FDB15EB00BA6
P2860
Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Differences in a conformationa ...... -oxide synthase flavoproteins.
@ast
Differences in a conformationa ...... -oxide synthase flavoproteins.
@en
type
label
Differences in a conformationa ...... -oxide synthase flavoproteins.
@ast
Differences in a conformationa ...... -oxide synthase flavoproteins.
@en
prefLabel
Differences in a conformationa ...... -oxide synthase flavoproteins.
@ast
Differences in a conformationa ...... -oxide synthase flavoproteins.
@en
P2093
P2860
P356
P1476
Differences in a conformationa ...... c-oxide synthase flavoproteins
@en
P2093
David W Konas
Deborah Durra
Dennis J Stuehr
Mauro Tiso
Robielyn P Ilagan
Russ Hille
P2860
P304
19603-19615
P356
10.1074/JBC.M802914200
P407
P50
P577
2008-05-16T00:00:00Z