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Application of PK/PD Modeling in Veterinary Field: Dose Optimization and Drug Resistance PredictionModelling and simulation as research tools in paediatric drug developmentImplementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical ResearchPharmacokinetic-Pharmacodynamic Modeling of Alpha Interferon Response Induced by a Toll-Like 7 Receptor Agonist in MiceThe Simcyp population-based ADME simulatorThe pharmacokinetic-pharmacodynamic model of azithromycin for lipopolysaccharide-induced depressive-like behavior in miceLeveraging systems biology approaches in clinical pharmacologyAgent-Based Modeling in Systems PharmacologyCPT: Pharmacometrics and Systems PharmacologyBasic Concepts in Population Modeling, Simulation, and Model-Based Drug DevelopmentGetReal in mathematical modelling: a review of studies predicting drug effectiveness in the real world.Comparisons of Analysis Methods for Proof-of-Concept Trials.White paper: landscape on technical and conceptual requirements and competence framework in drug/disease modeling and simulation.Clinical Trial Simulation to Inform Phase 2: Comparison of Concentrated vs. Distributed First-in-Patient Study Designs in Psoriasis.A linearization approach for the model-based analysis of combined aggregate and individual patient data.Automated analysis of routinely generated preclinical pharmacokinetic and pharmacodynamic data.Osteoarthritis disease progression model using six year follow-up data from the osteoarthritis initiative.The Many Flavors of Model-Based Meta-Analysis: Part I-Introduction and Landmark Data.Literature mining on pharmacokinetics numerical data: a feasibility studyQuantitative pharmacology approach in Alzheimer's disease: efficacy modeling of early clinical data to predict clinical outcome of tesofensine.Translational pharmacokinetic-pharmacodynamic modelling; application to cardiovascular safety data for PF-00821385, a novel HIV agent.Non-compartment model to compartment model pharmacokinetics transformation meta-analysis--a multivariate nonlinear mixed modelDifficulties in Treatment and Management of Epilepsy and Challenges in New Drug DevelopmentA zinc-binding site by negative selection induces metallodrug susceptibility in an essential chaperonin.Confidence from uncertainty--a multi-target drug screening method from robust control theory.Application of quantitative pharmacology in development of therapeutic monoclonal antibodiesIntegrated pharmacometrics and systems pharmacology model-based analyses to guide GnRH receptor modulator development for management of endometriosis.Linking the population pharmacokinetics of tenofovir and its metabolites with its cellular uptake and metabolism.Use of quantitative pharmacology in the development of HAE1, a high-affinity anti-IgE monoclonal antibody.Concepts and challenges in quantitative pharmacology and model-based drug development.Interpreting population pharmacokinetic-pharmacodynamic analyses - a clinical viewpoint.A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair.Implementation of quantitative and systems pharmacology in large pharma.Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendationsExposure-response model for sibutramine and placebo: suggestion for application to long-term weight-control drug developmentPopulation pharmacokinetic-pharmacodynamic-disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis.Reflections on the Adaptive Designs Accelerating Promising Trials Into Treatments (ADAPT-IT) Process-Findings from a Qualitative Study.Evaluating a physiologically based pharmacokinetic model for predicting the pharmacokinetics of midazolam in Chinese after oral administration.A model qualification method for mechanistic physiological QSP models to support model-informed drug development.Good Practices in Model-Informed Drug Discovery and Development: Practice, Application, and Documentation
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Model-based drug development.
@en
type
label
Model-based drug development.
@en
prefLabel
Model-based drug development.
@en
P2093
P356
P1476
Model-based drug development.
@en
P2093
B W Corrigan
D J Nichols
K G Kowalski
L J Benincosa
M M Hutmacher
P A Lockwood
P A Milligan
P356
10.1038/SJ.CLPT.6100235
P407
P50
P577
2007-05-23T00:00:00Z