Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells.
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Targeting histone methyltransferases and demethylases in clinical trials for cancer therapyHistone Deacetylases Exert Class-Specific Roles in Conditioning the Brain and Heart Against Acute Ischemic InjuryKDM1 class flavin-dependent protein lysine demethylasesHistone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cellsHigh nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients.RGS16, a novel p53 and pRb cross-talk candidate inhibits migration and invasion of pancreatic cancer cells.Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometryDepletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair.Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma.Tranylcypromine, a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis.miR-708/LSD1 axis regulates the proliferation and invasion of breast cancer cells.Epigenetic regulation of LSD1 during mammary carcinogenesis.Epigenetic perspectives on cancer chemotherapy response.Epigenetic reprogramming in breast cancer: from new targets to new therapies.Regulation of Wnt signaling by protocadherins.Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.Functional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression.RGS16 restricts the pro-inflammatory response of monocytes.HDACs and HDAC Inhibitors in Cancer Development and Therapy.Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells.Epigenetic therapy approaches in non-small cell lung cancer: Update and perspectives.Histone Lysine Demethylase Inhibitors.An epigenetic switch regulates de novo DNA methylation at a subset of pluripotency gene enhancers during embryonic stem cell differentiation.MAGE-TRIM28 complex promotes the Warburg effect and hepatocellular carcinoma progression by targeting FBP1 for degradation.Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells.Epigenetic Mechanisms of Tamoxifen Resistance in Luminal Breast Cancer.Functional characterization of lysine-specific demethylase 2 (LSD2/KDM1B) in breast cancer progression.Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a, potentially affecting CDKN1C expression.Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer.HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells.KDM1A microenvironment, its oncogenic potential, and therapeutic significance.
P2860
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P2860
Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Crosstalk between lysine-speci ...... in human breast cancer cells.
@en
type
label
Crosstalk between lysine-speci ...... in human breast cancer cells.
@en
prefLabel
Crosstalk between lysine-speci ...... in human breast cancer cells.
@en
P2093
P2860
P356
P1433
P1476
Crosstalk between lysine-speci ...... in human breast cancer cells.
@en
P2093
Nancy E Davidson
Shauna N Vasilatos
Steffi Oesterreich
Tiffany A Katz
P2860
P304
P356
10.1093/CARCIN/BGT033
P407
P577
2013-01-25T00:00:00Z