Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease.
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Lysophospholipids and their receptors in the central nervous systemFingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapyPathology of GM2 gangliosidosis in Jacob sheepIminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff diseaseUnmasking of LPA1 receptor-mediated migration response to lysophosphatidic acid by interleukin-1β-induced attenuation of Rho signaling pathways in rat astrocytesSphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditionsFcRγ-dependent immune activation initiates astrogliosis during the asymptomatic phase of Sandhoff disease model miceCharacterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretomeSphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes.Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis.Cellular localization of sphingosine-1-phosphate receptor 1 expression in the human central nervous systemSphingolipids in multiple sclerosis.FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation.Regulating survival and development in the retina: key roles for simple sphingolipids.Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model.Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy.Ethanol triggers sphingosine 1-phosphate elevation along with neuroapoptosis in the developing mouse brain.Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C.Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling.Astrocytes and lysosomal storage diseases.Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathwaysLysosomal Storage Diseases-Regulating Neurodegeneration.A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya).Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes.Sphingosine-1-phosphate receptor 3 influences cell cycle progression in muscle satellite cells.FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous systemRoles for lysophospholipid S1P receptors in multiple sclerosis.FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination.Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis.Neuron-astroglial interactions in cell-fate commitment and maturation in the central nervous system.Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids.AAV-mediated gene delivery attenuates neuroinflammation in feline Sandhoff disease.Lipidomic Evaluation of Feline Neurologic Disease after AAV Gene Therapy.Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies.The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination.S1P1 deletion in oligodendroglial lineage cells: Effect on differentiation and myelination.Deletion of tumor necrosis factor-α ameliorates neurodegeneration in Sandhoff disease mice.Cerebral organoids derived from Sandhoff disease induced pluripotent stem cells exhibit impaired neurodifferentiation.Neuronal pentraxin 1 depletion delays neurodegeneration and extends life in Sandhoff disease mice.Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide.
P2860
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P2860
Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Sphingosine kinase 1/S1P recep ...... in mice with Sandhoff disease.
@en
type
label
Sphingosine kinase 1/S1P recep ...... in mice with Sandhoff disease.
@en
prefLabel
Sphingosine kinase 1/S1P recep ...... in mice with Sandhoff disease.
@en
P2093
P2860
P356
P1476
Sphingosine kinase 1/S1P recep ...... in mice with Sandhoff disease
@en
P2093
Kiyomi Mizugishi
Meryem Bektas
Roger Sandhoff
Yun-Ping Wu
P2860
P304
P356
10.1093/HMG/DDN126
P577
2008-04-17T00:00:00Z