Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading.
about
Gap junctional regulation of signal transduction in bone cellsFunctions of the osteocyte network in the regulation of bone massOsteocytes: master orchestrators of bonePhysiological mechanisms and therapeutic potential of bone mechanosensing.The current state of bone loss research: data from spaceflight and microgravity simulators.Interdependence of muscle atrophy and bone loss induced by mechanical unloadingOsteocyte-Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots.Inhibition of GSK-3β rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice.Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysisCx43 and mechanotransduction in bone.Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodelingConnexins and pannexins in the skeleton: gap junctions, hemichannels and moreRole of connexins and pannexins during ontogeny, regeneration, and pathologies of boneMechanical Loading Attenuates Radiation-Induced Bone Loss in Bone Marrow Transplanted MiceDefective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain.Beyond gap junctions: Connexin43 and bone cell signalingConnexins in the skeletonConnexin43 modulates post-natal cortical bone modeling and mechano-responsiveness.Mouse models for the evaluation of osteocyte functions.Molecular mechanisms of osteoblast/osteocyte regulation by connexin43.Osteoporosis-bone remodeling and animal models.Bone cell senescence: mechanisms and perspectives.Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load.The "connexin" between bone cells and skeletal functions.Microgravity Stress: Bone and Connective Tissue.Simulated space radiation sensitizes bone but not muscle to the catabolic effects of mechanical unloading.Mechanosensitive miRNAs and Bone FormationBlockage of hemichannels alters gene expression in osteocytes in a high magneto-gravitational environment.Biological responses of osteocytic connexin 43 hemichannels to simulated microgravity.Connexin43 and Runx2 Interact to Affect Cortical Bone Geometry, Skeletal Development, and Osteoblast and Osteoclast Function.The G60S connexin 43 mutation activates the osteoblast lineage and results in a resorption-stimulating bone matrix and abrogation of old-age-related bone loss.Gap junction mediated regulation of osteocytes to osteoblastic alkaline phosphatase activity is independent of microgravity
P2860
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P2860
Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Connexin 43 deficiency attenua ...... ne formation during unloading.
@en
type
label
Connexin 43 deficiency attenua ...... ne formation during unloading.
@en
prefLabel
Connexin 43 deficiency attenua ...... ne formation during unloading.
@en
P2093
P2860
P356
P1476
Connexin 43 deficiency attenua ...... ne formation during unloading.
@en
P2093
Emmanuel M Paul
Gregory S Lewis
Henry J Donahue
Shane A Lloyd
P2860
P304
P356
10.1002/JBMR.1687
P577
2012-11-01T00:00:00Z