alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice
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The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretionα-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8Human T regulatory cell therapy: take a billion or so and call me in the morningSurvival of encapsulated islets: More than a membrane storyT Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, α1-AntitrypsinImmune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experienceAcute-phase protein α1-anti-trypsin: diverting injurious innate and adaptive immune responses from non-authentic threatsMechanistic evidence in support of alpha1-antitrypsin as a therapeutic approach for type 1 diabetesExpanding the clinical indications for α(1)-antitrypsin therapyAging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitorsContext-Specific and Immune Cell-Dependent Antitumor Activities of α1-AntitrypsinBALB/c mice show impaired hepatic tolerogenic response following AAV gene transfer to the liver.α1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1β responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes.Aspiration, localized pulmonary inflammation, and predictors of early-onset bronchiolitis obliterans syndrome after lung transplantationInvestigating and Annotating the Role of Citation in Biomedical Full-Text Articlesα-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics.Creating transplant tolerance by taming adverse intragraft innate immunity.Pancreatic islet xenograft survival in mice is extended by a combination of alpha-1-antitrypsin and single-dose anti-CD4/CD8 therapy.The immunoregulation effect of alpha 1-antitrypsin prolong β-cell survival after transplantationInnate immune activation by tissue injury and cell death in the setting of hematopoietic stem cell transplantation.α-1-antitrypsin gene delivery reduces inflammation, increases T-regulatory cell population size and prevents islet allograft rejectionInhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation.Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus.Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival.Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury.Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantationInsulin degradation by acinar cell proteases creates a dysfunctional environment for human islets before/after transplantation: benefits of α-1 antitrypsin treatmentEffect of recombinant α1-antitrypsin Fc-fused (AAT-Fc)protein on the inhibition of inflammatory cytokine production and streptozotocin-induced diabetes.Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.Anti-inflammatory Agents: Present and FutureThe complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritisAlpha-1 antitrypsin reduces severity of pseudomonas pneumonia in mice and inhibits epithelial barrier disruption and pseudomonas invasion of respiratory epithelial cellsImmunologic basis of graft rejection and tolerance following transplantation of liver or other solid organsRegulatory B cells and tolerance in transplantation: from animal models to human.Exploration of α1-antitrypsin treatment protocol for islet transplantation: dosing plan and route of administration.The role of complement in the early immune response to transplantation.Immune-modulating effects of alpha-1 antitrypsin.The multiple facets of alpha-1-antitrypsin.Immune protective effect of human alpha-1-antitrypsin gene during β cell transplantation in diabetic mice.
P2860
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P2860
alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
alpha1-Antitrypsin monotherapy ...... ograft transplantation in mice
@en
type
label
alpha1-Antitrypsin monotherapy ...... ograft transplantation in mice
@en
prefLabel
alpha1-Antitrypsin monotherapy ...... ograft transplantation in mice
@en
P2093
P2860
P356
P1476
alpha1-Antitrypsin monotherapy ...... ograft transplantation in mice
@en
P2093
Andrew Churg
Eli C Lewis
Joanne L Wright
Leland Shapiro
Mark Mizrahi
Michel Toledano
Nathaniel Defelice
P2860
P304
16236-16241
P356
10.1073/PNAS.0807627105
P407
P577
2008-10-13T00:00:00Z