Membrane-anchored serine proteases in health and disease.
about
HATL5: a cell surface serine protease differentially expressed in epithelial cancersRole of corin and atrial natriuretic peptide in preeclampsiaProteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin.N-glycosylation is required for matriptase-2 autoactivation and ectodomain sheddingExpression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HATCorin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment.Corin in natriuretic peptide processing and hypertensionPericellular proteolysis in cancerDistinct roles of N-glycosylation at different sites of corin in cell membrane targeting and ectodomain shedding.A corin variant identified in hypertensive patients that alters cytoplasmic tail and reduces cell surface expression and activityCombinatorial tuning of peptidic drug candidates: high-affinity matriptase inhibitors through incremental structure-guided optimization.The expression of TMPRSS4 and Erk1 correlates with metastasis and poor prognosis in Chinese patients with gastric cancerProteolytic activation of the protease-activated receptor (PAR)-2 by the glycosylphosphatidylinositol-anchored serine protease testisin.Corin in clinical laboratory diagnosticsHost cell proteases: Critical determinants of coronavirus tropism and pathogenesisA novel cytoplasmic tail motif regulates mouse corin expression on the cell surface.Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden.Membrane-anchored proteases in endothelial cell biology.High Hepsin expression predicts poor prognosis in Gastric Cancer.Overexpression of TMPRSS4 promotes tumor proliferation and aggressiveness in breast cancerThe Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss.Association of CTRC and SPINK1 gene variants with recurrent hospitalizations for pancreatitis or acute abdominal pain in lipoprotein lipase deficiencyPhosphorylation of the type II transmembrane serine protease, TMPRSS13 in Hepatocyte Growth Factor Activator Inhibitor-1 and 2-mediated cell surface localization.Inhibitory effect of FSLLRY-NH2 on inflammatory responses induced by hydrogen peroxide in HepG2 cells.The role of type II transmembrane serine protease-mediated signaling in cancer.Human airway trypsin-like protease, a serine protease involved in respiratory diseases.Strong expression association between matriptase and its substrate prostasin in breast cancer.Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin.Design and synthesis of potent, selective inhibitors of matriptase.In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells.Gallium Nanoparticle-Mediated Reduction of Brain Specific Serine Protease-4 in an Experimental Metastatic Cancer ModelThe type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β amyloid.The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover.Functional analysis of corin protein domains required for PCSK6-mediated activation.Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia.MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis.Changing the selectivity profile - from substrate analog inhibitors of thrombin and factor Xa to potent matriptase inhibitors.
P2860
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P2860
Membrane-anchored serine proteases in health and disease.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Membrane-anchored serine proteases in health and disease.
@en
type
label
Membrane-anchored serine proteases in health and disease.
@en
prefLabel
Membrane-anchored serine proteases in health and disease.
@en
P2860
P1476
Membrane-anchored serine proteases in health and disease
@en
P2093
Toni M Antalis
P2860
P356
10.1016/B978-0-12-385504-6.00001-4
P577
2011-01-01T00:00:00Z