Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line
about
Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.Packaging cells based on inducible gene amplification for the production of adeno-associated virus vectorsAmplification of EGFR T790M causes resistance to an irreversible EGFR inhibitorIdentification of methotrexate transport deficiency in mammalian cells using fluoresceinated methotrexate and flow cytometryPersistent DNA damage inhibits S-phase and G2 progression, and results in apoptosisPresence of negative torsional tension in the promoter region of the transcriptionally poised dihydrofolate reductase gene in vivoStability of protein production from recombinant mammalian cells.Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.Fifth Gordon Hamilton-Fairley memorial lecture. Methotrexate resistance and gene amplification: an experimental model for the generation of cellular heterogeneityDeterminants of trimetrexate lethality in human colon cancer cellsGene amplification accompanies low level increases in the activity of dihydrofolate reductase in antifolate-resistant Chinese hamster lung cells containing abnormally banding chromosomes.A UV-responsive G2 checkpoint in rodent cells.Gene-specific and strand-specific DNA repair in the G1 and G2 phases of the cell cycle.Chromosomal destabilization during gene amplification.Demethylation enhances removal of pyrimidine dimers from the overall genome and from specific DNA sequences in Chinese hamster ovary cellsIntroduction of YACs containing a putative mammalian replication origin into mammalian cells can generate structures that replicate autonomously.Double minute chromosomes can be produced from precursors derived from a chromosomal deletionUnstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification.Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication originFormation of an inverted duplication can be an initial step in gene amplification.Replication of herpes simplex virus type 1 on hydroxyurea-resistant baby hamster kidney cellsConstruction and use of a dominant, selectable marker: a Harvey sarcoma virus-dihydrofolate reductase chimeraChromosomal alterations associated with overproduction of asparagine synthetase in albizziin-resistant Chinese hamster ovary cells.Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.Co-amplification of double minute chromosomes, multiple drug resistance, and cell surface P-glycoprotein in DNA-mediated transformants of mouse cells.UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.Correlation of unstable multidrug cross resistance in Chinese hamster ovary cells with a homogeneously staining region on chromosome 1.Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyureaRapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sortingA framework to quantify karyotype variation associated with CHO cell line instability at a single-cell level.Transcription-coupled repair is inducible in hamster cells.Methotrexate resistance and gene amplification. Mechanisms and implications.Heterogeneity of human colon carcinoma.Molecular biology of double-minute chromosomes.Gene amplification in human gliomas.Localization of a bidirectional DNA replication origin in the native locus and in episomally amplified murine adenosine deaminase loci.Effect of cloned gene dosage on cell growth and hepatitis B surface antigen synthesis and secretion in recombinant CHO cells.Characterization by flow cytometry of fluorescein-methotrexate transport in Chinese hamster ovary cells.
P2860
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P2860
Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line
description
1981 nî lūn-bûn
@nan
1981年の論文
@ja
1981年論文
@yue
1981年論文
@zh-hant
1981年論文
@zh-hk
1981年論文
@zh-mo
1981年論文
@zh-tw
1981年论文
@wuu
1981年论文
@zh
1981年论文
@zh-cn
name
Amplification and loss of dihy ...... hinese hamster ovary cell line
@en
type
label
Amplification and loss of dihy ...... hinese hamster ovary cell line
@en
prefLabel
Amplification and loss of dihy ...... hinese hamster ovary cell line
@en
P2860
P356
P1476
Amplification and loss of dihy ...... hinese hamster ovary cell line
@en
P2093
R J Kaufman
R T Schimke
P2860
P304
P356
10.1128/MCB.1.12.1069
P407
P577
1981-12-01T00:00:00Z