Structure-based discovery of antagonists of nuclear receptor LRH-1.
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Insights into Orphan Nuclear Receptors as Prognostic Markers and Novel Therapeutic Targets for Breast CancerCrystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of ActivationLigand pose and orientational sampling in molecular dockingThe human orphan nuclear receptor tailless (TLX, NR2E1) is druggableDisulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner.Nuclear receptors and pathogenesis of pancreatic cancer.Antiproliferation activity of a small molecule repressor of liver receptor homolog 1Structure-based virtual screening for drug discovery: principles, applications and recent advances.Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regressionLiver receptor homolog-1 (LRH-1): a potential therapeutic target for cancerStructure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket.Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.Liver receptor homolog 1 influences blastocyst hatching in pigsThe characterization of an intestine-like genomic signature maintained during Barrett's-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival.LRH1 as a driving factor in pancreatic cancer growthExploring the molecular basis for selective binding of homoserine dehydrogenase from Mycobacterium leprae TN toward inhibitors: a virtual screening studyWhy does the gut synthesize glucocorticoids?Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas developmentSERBP1 Is a Component of the Liver Receptor Homologue-1 Transcriptional Complex.Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcription and associated T-cell effector functions.NR5A2 discovering compounds that block tumor growth in PDAC.Human sperm liver receptor homolog-1 (LRH-1) acts as a downstream target of the estrogen signaling pathway.Nuclear receptor NR5A2 controls neural stem cell fate decisions during development.LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness.Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1
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Structure-based discovery of antagonists of nuclear receptor LRH-1.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 May 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Structure-based discovery of antagonists of nuclear receptor LRH-1.
@en
Structure-based discovery of antagonists of nuclear receptor LRH-1.
@nl
type
label
Structure-based discovery of antagonists of nuclear receptor LRH-1.
@en
Structure-based discovery of antagonists of nuclear receptor LRH-1.
@nl
prefLabel
Structure-based discovery of antagonists of nuclear receptor LRH-1.
@en
Structure-based discovery of antagonists of nuclear receptor LRH-1.
@nl
P2093
P2860
P50
P356
P1476
Structure-based discovery of antagonists of nuclear receptor LRH-1.
@en
P2093
Allison K Doak
Cindy Benod
Elena P Sablin
Peter Hwang
Robert J Fletterick
Rubatharshini Uthayaruban
P2860
P304
19830-19844
P356
10.1074/JBC.M112.411686
P407
P577
2013-05-10T00:00:00Z