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Targeted Disruption of the Interaction Between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase ComplexesEpigenetics in normal and malignant hematopoiesis: An overview and update 2017.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Striking differences between knockout and wild-type mice in global gene expression variabilityMusashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement.Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells.MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemiaDeconvoluting MLL1-dependent pathways in hematopoiesis and leukemogenesis.Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis.Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells.Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.BRPF1 is essential for development of fetal hematopoietic stem cellsDpy30 is critical for maintaining the identity and function of adult hematopoietic stem cellsTargeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.Epigenetic modifiers in normal and malignant hematopoiesis.Formula G1: Cell cycle in the driver's seat of stem cell fate determination.NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB.The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesisPRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity.Cell context in the control of self-renewal and proliferation regulated by MLL1.Trithorax group genes in hematopoiesis.The subtype-specific features of EVI1 and PRDM16 in acute myeloid leukemia.CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: redefinition of murine common myeloid progenitor.MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells.The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 06 June 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
An MLL-dependent network sustains hematopoiesis.
@en
An MLL-dependent network sustains hematopoiesis.
@nl
type
label
An MLL-dependent network sustains hematopoiesis.
@en
An MLL-dependent network sustains hematopoiesis.
@nl
prefLabel
An MLL-dependent network sustains hematopoiesis.
@en
An MLL-dependent network sustains hematopoiesis.
@nl
P2093
P2860
P356
P1476
An MLL-dependent network sustains hematopoiesis
@en
P2093
Adrian W Moore
Bibhu P Mishra
Chao Cheng
Elaine K Y Chung
Erika L Artinger
Kristin M Zaffuto
Yufei Chen
P2860
P304
12000-12005
P356
10.1073/PNAS.1301278110
P407
P50
P577
2013-06-06T00:00:00Z