Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
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PINK1 is selectively stabilized on impaired mitochondria to activate ParkinFunctional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's diseaseThe mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 traffickingRac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagyThe role of oxidative stress in Parkinson's diseaseParkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stressPhosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signalingStructural insights into oligomerization and mitochondrial remodelling of dynamin 1-like proteinGenome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson diseaseMitochondria, calcium and cell death: a deadly triad in neurodegenerationA mitochondrial protein compendium elucidates complex I disease biologyParkinson's Disease: The Mitochondria-Iron LinkNeuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent PerspectivesThe Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative DiseasesNeuroprotective Transcription Factors in Animal Models of Parkinson DiseaseThe Role of Oxidative Stress in Neurodegenerative DiseasesUnfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion DiseasesRedox control of protein degradationOxidative stress and Parkinson's diseaseParkinson's disease, insulin resistance and novel agents of neuroprotectionMetabolomics of human brain aging and age-related neurodegenerative diseasesMetabolic disturbances in diseases with neurological involvementSomatic mutations in aging, cancer and neurodegenerationUpstream deregulation of calcium signaling in Parkinson's diseaseMechanisms of mitophagyOxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiaeConverging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's diseaseThe relationship between glucocerebrosidase mutations and Parkinson diseaseEffects of 6-hydroxydopamine exposure on motor activity and biochemical expression in zebrafish (Danio rerio) larvaeParkin is protective against proteotoxic stress in a transgenic zebrafish modelMutant Parkin impairs mitochondrial function and morphology in human fibroblastsBioenergetic consequences of PINK1 mutations in Parkinson diseaseOxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's DiseasePINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagyParkinson's Disease and Cognitive ImpairmentRelationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissuesReduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy.Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice.
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Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
@en
Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
@nl
type
label
Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
@en
Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
@nl
prefLabel
Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
@en
Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
@nl
P921
P1433
P1476
Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
@en
P304
P356
10.1016/S1474-4422(07)70327-7
P577
2008-01-01T00:00:00Z