Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.

Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.

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http://www.wikidata.org/entity/Q37040604

Q37040604

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Molecular mechanisms of silibinin-mediated cancer chemoprevention with major emphasis on prostate cancer Chemopreventive and anti-cancer efficacy of silibinin against growth and progression of lung cancer Broad targeting of angiogenesis for cancer prevention and therapy The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms Knockout of the tumor suppressor gene Gprc5a in mice leads to NF-kappaB activation in airway epithelium and promotes lung inflammation and tumorigenesis Silibinin can induce differentiation as well as enhance vitamin D3-induced differentiation of human AML cells ex vivo and regulates the levels of differentiation-related transcription factors.Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells.Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).Regulation of cytokine-induced prostanoid and nitric oxide synthesis by extracellular signal–regulated kinase 1/2 in lung epithelial cells.Tumor cells and tumor-associated macrophages: secreted proteins as potential targets for therapy.Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells.Natural Agents Used in Chemoprevention of Aerodigestive and GI Cancers Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network.Plants and their active compounds: natural molecules to target angiogenesis.Targeting tumor-infiltrating macrophages to combat cancer.Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers Targeting tumor microenvironment with silibinin: promise and potential for a translational cancer chemopreventive strategy.Silibinin inhibits prostate cancer cells- and RANKL-induced osteoclastogenesis by targeting NFATc1, NF-κB, and AP-1 activation in RAW264.7 cells.Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer.Targeting silibinin in the antiproliferative pathway.Anti-tumour strategies aiming to target tumour-associated macrophages.Tumor necrosis factor-alpha-converting enzyme activities and tumor-associated macrophages in breast cancer.Emerging role of tumor-associated macrophages as therapeutic targets in patients with metastatic renal cell carcinoma.A Review: Phytochemicals Targeting JAK/STAT Signaling and IDO Expression in Cancer.Silibinin suppresses NPM-ALK, potently induces apoptosis and enhances chemosensitivity in ALK-positive anaplastic large cell lymphoma.STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma.The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells.Silibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells.Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells.SR16388: a steroidal antiangiogenic agent with potent inhibitory effect on tumor growth in vivo.Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin.Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway.Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies.Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer.Silibinin Effect on Fas/FasL, HMGB1, and CD45 Expressions in a Rat Model Subjected to Liver Ischemia-Reperfusion Injury.Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis.Silibinin attenuates oxidative metabolism and cytokine production by monocytes from preeclamptic women.Effects of silibinin-loaded thermosensitive liposome-microbubble complex on inhibiting rabbit liver VX2 tumors in sub-hyperthermia fields.TNF-α expression in Schwann cells is induced by LPS and NF-κB-dependent pathways.

P2860

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P2860

Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.

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http://www.wikidata.org/entity/Q37040604

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on January 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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