Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts
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A genome-wide screen for genetic variants that modify the recruitment of REST to its target genesIn vitro selection of mutant HDM2 resistant to Nutlin inhibitionAn African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse modelConservation of DNA-binding specificity and oligomerisation properties within the p53 family.Lysine120 interactions with p53 response elements can allosterically direct p53 organization.Single-nucleotide polymorphisms in the p53 signaling pathway.The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.A functional p53 responsive polymorphism in KITLG, rs4590952, does not affect the risk of breast cancer.p53 Isoforms: An Intracellular Microprocessor?Widespread site-dependent buffering of human regulatory polymorphism.A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection.Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements.Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk.Rapid and Sensitive Detection of p53 Based on DNA-Protein Binding Interactions Using Silver Nanoparticle Films and Microwave Heating.Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elementsInteractions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation.Whole-genome cartography of p53 response elements ranked on transactivation potential.Low-level p53 expression changes transactivation rules and reveals superactivating sequences.Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerensRegulation of carboxylesterase-2 expression by p53 family proteins and enhanced anti-cancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug.True equilibrium measurement of transcription factor-DNA binding affinities using automated polarization microscopy.A novel molecular rotor facilitates detection of p53-DNA interactions using the Fluorescent Intercalator Displacement AssayRevealing a human p53 universe
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P2860
Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Probing the functional impact ...... nding with human cell extracts
@en
Probing the functional impact ...... ding with human cell extracts.
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type
label
Probing the functional impact ...... nding with human cell extracts
@en
Probing the functional impact ...... ding with human cell extracts.
@nl
prefLabel
Probing the functional impact ...... nding with human cell extracts
@en
Probing the functional impact ...... ding with human cell extracts.
@nl
P2093
P2860
P1433
P1476
Probing the functional impact ...... nding with human cell extracts
@en
P2093
Brian N Chorley
Daniel Menendez
Douglas A Bell
Gary S Pittman
Maher A Noureddine
Michelle R Campbell
Monica M Horvath
Omari J Bandele
P2860
P304
P356
10.1371/JOURNAL.PGEN.1000462
P577
2009-05-08T00:00:00Z