Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation
about
Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesisDifferent levels of the Tripartite motif protein, Anomalies in sensory axon patterning (Asap), regulate distinct axonal projections of Drosophila sensory neuronsAbelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans.A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling.Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epitheliaLamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo.Mal/SRF is dispensable for cell proliferation in Drosophila.Control of cell adhesion dynamics by Rap1 signaling.Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice.A pathogenic relationship between a regulator of the actin cytoskeleton and serum response factorValidating RNAi phenotypes in Drosophila using a synthetic RNAi-resistant transgene.Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons.Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments.Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motilityFilopodia-like actin cables position nuclei in association with perinuclear actin in Drosophila nurse cells.Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells.Transcriptional responses to hyperplastic MRL signalling in Drosophila.Metastasis: tumor cells becoming MENAcing.Rap1-GTP-interacting adaptor molecule (RIAM) protein controls invasion and growth of melanoma cells.MRL proteins cooperate with activated Ras in glia to drive distinct oncogenic outcomes.Talin autoinhibition is required for morphogenesis.
P2860
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P2860
Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年學術文章
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2008年學術文章
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2008年學術文章
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name
Drosophila pico and its mammal ...... and promote cell proliferation
@en
Drosophila pico and its mammal ...... nd promote cell proliferation.
@nl
type
label
Drosophila pico and its mammal ...... and promote cell proliferation
@en
Drosophila pico and its mammal ...... nd promote cell proliferation.
@nl
prefLabel
Drosophila pico and its mammal ...... and promote cell proliferation
@en
Drosophila pico and its mammal ...... nd promote cell proliferation.
@nl
P2093
P2860
P1433
P1476
Drosophila pico and its mammal ...... and promote cell proliferation
@en
P2093
Adam Fletcher
Anne Vehlow
Daimark Bennett
Ekaterina Lyulcheva
Eleanor Taylor
Magdalene Michael
Matthias Krause
Shengjiang Tan
P2860
P304
P356
10.1016/J.DEVCEL.2008.09.020
P407
P577
2008-11-01T00:00:00Z