Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.
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Kinases as druggable targets in trypanosomatid protozoan parasitesAcinetobacter baumanniiFolD ligand complexes - potent inhibitors of folate metabolism and a re-evaluation of the structure of LY374571The crystal structure of Leishmania major N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug targetAssessment of Pseudomonas aeruginosa N5,N10-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug TargetDecoupling Environment-Dependent and Independent Genetic Robustness across Bacterial SpeciesLmaPA2G4, a homolog of human Ebp1, is an essential gene and inhibits cell proliferation in L. majorTargeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylaseFunctional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania.Genetic metabolic complementation establishes a requirement for GDP-fucose in Leishmania.Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage.Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity.'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicanaThe enzymes of the 10-formyl-tetrahydrofolate synthetic pathway are found exclusively in the cytosol of the trypanosomatid parasite Leishmania major.Kinetoplastid-specific histone variant functions are conserved in Leishmania major.Folate metabolic pathways in LeishmaniaProbing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.One-carbon metabolic pathway rewiring in Escherichia coli reveals an evolutionary advantage of 10-formyltetrahydrofolate synthetase (Fhs) in survival under hypoxia.Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei.Genetically Validated Drug Targets in Leishmania; Current Knowledge and Future Prospects.Leishmania IFT140 mutants show normal viability but lack external flagella: a tool for the study of flagellar function through the infectious cycle.
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Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Methylene tetrahydrofolate deh ...... essential in Leishmania major.
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Methylene tetrahydrofolate deh ...... essential in Leishmania major.
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type
label
Methylene tetrahydrofolate deh ...... essential in Leishmania major.
@en
Methylene tetrahydrofolate deh ...... essential in Leishmania major.
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prefLabel
Methylene tetrahydrofolate deh ...... essential in Leishmania major.
@en
Methylene tetrahydrofolate deh ...... essential in Leishmania major.
@nl
P2860
P1476
Methylene tetrahydrofolate deh ...... essential in Leishmania major.
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P2093
David A Scott
Silvane M F Murta
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P304
P356
10.1111/J.1365-2958.2009.06610.X
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P577
2009-01-16T00:00:00Z