Syk and pTyr'd: Signaling through the B cell antigen receptor
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The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85Targeting Syk in Autoimmune Rheumatic DiseasesStress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease.The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesisTwo Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with VavDifferential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domainIdentification of type-II inhibitors using kinase structuresImidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP)Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophagesA respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signalingFormation of a mast cell synapse: Fc epsilon RI membrane dynamics upon binding mobile or immobilized ligands on surfaces.The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly.B cell activation triggered by the formation of the small receptor cluster: a computational study.Complex phosphorylation dynamics control the composition of the Syk interactome in B cells.Getting Syk: spleen tyrosine kinase as a therapeutic target.Tyrosines in the carboxyl terminus regulate Syk kinase activity and functionThe CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.Regulation of Syk by phosphorylation on serine in the linker insertSpecific visualization and identification of phosphoproteome in gels.Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrapNanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B.Regulation and function of syk tyrosine kinase in mast cell signaling and beyond.In-Depth Analyses of B Cell Signaling Through Tandem Mass Spectrometry of Phosphopeptides Enriched by PolyMAC.The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74.A multi-histology trial of fostamatinib in patients with advanced colorectal, non-small cell lung, head and neck, thyroid, and renal cell carcinomas, and pheochromocytomas.Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular storesCorrelation of disease activity in proliferative glomerulonephritis with glomerular spleen tyrosine kinase expression.Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.A computational model for early events in B cell antigen receptor signaling: analysis of the roles of Lyn and Fyn.A Computational Study of the Effects of Syk Activity on B Cell Receptor Signaling DynamicsSyk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy.Jedi-1 and MEGF10 signal engulfment of apoptotic neurons through the tyrosine kinase Syk.A peptide-based biosensor assay to detect intracellular Syk kinase activation and inhibition.Single-cell measurements of IgE-mediated FcεRI signaling using an integrated microfluidic platformSyk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunitFormation of BCR oligomers provides a mechanism for B cell affinity discrimination.Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells.
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Syk and pTyr'd: Signaling through the B cell antigen receptor
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 21 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Syk and pTyr'd: Signaling through the B cell antigen receptor
@en
Syk and pTyr'd: Signaling through the B cell antigen receptor.
@nl
type
label
Syk and pTyr'd: Signaling through the B cell antigen receptor
@en
Syk and pTyr'd: Signaling through the B cell antigen receptor.
@nl
prefLabel
Syk and pTyr'd: Signaling through the B cell antigen receptor
@en
Syk and pTyr'd: Signaling through the B cell antigen receptor.
@nl
P2860
P1476
Syk and pTyr'd: Signaling through the B cell antigen receptor
@en
P2093
Robert L Geahlen
P2860
P304
P356
10.1016/J.BBAMCR.2009.03.004
P407
P577
2009-03-21T00:00:00Z