Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability.
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Yeast Nej1 is a key participant in the initial end binding and final ligation steps of nonhomologous end joining.Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcsRole of non-homologous end joining in V(D)J recombinationAbsence of p53-dependent apoptosis combined with nonhomologous end-joining deficiency leads to a severe diabetic phenotype in mice.Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiencyPolynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease and can participate in DNA end joining in a biochemical system.Functional analysis of naturally occurring DCLRE1C mutations and correlation with the clinical phenotype of ARTEMIS deficiencyUnifying the DNA end-processing roles of the artemis nuclease: Ku-dependent artemis resection at blunt DNA ends.Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complexDealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair.Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ.Severe combined immunodeficiences: new and old scenarios.Repair of double-strand breaks by end joining.The spatial organization of non-homologous end joining: from bridging to end joining.DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis.Linkage of catalysis and 5' end recognition in ribonuclease RNase J.Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repairNot All SCID Pigs Are Created Equally: Two Independent Mutations in the Artemis Gene Cause SCID in Pigs.A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis.MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.Autoinhibition of the Nuclease ARTEMIS Is Mediated by a Physical Interaction between Its Catalytic and C-terminal Domains.Expression and localization of Artemis serine 516 phosphorylation in human scalp skin.Achieving selectivity in space and time with DNA double-strand-break response and repair: molecular stages and scaffolds come with strings attached
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P2860
Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 06 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Impact of a hypomorphic Artemi ...... cessing, and genome stability.
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Impact of a hypomorphic Artemi ...... cessing, and genome stability.
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type
label
Impact of a hypomorphic Artemi ...... cessing, and genome stability.
@en
Impact of a hypomorphic Artemi ...... cessing, and genome stability.
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prefLabel
Impact of a hypomorphic Artemi ...... cessing, and genome stability.
@en
Impact of a hypomorphic Artemi ...... cessing, and genome stability.
@nl
P2093
P2860
P356
P1476
Impact of a hypomorphic Artemi ...... cessing, and genome stability.
@en
P2093
Gerwin Westfield
JoAnn Sekiguchi
Jordan St Charles
Laurel Chadde
Martina Kubec
Stephanie Kraftson
William Giblin
Ying Huang
P2860
P304
P356
10.1084/JEM.20082396
P407
P577
2009-04-06T00:00:00Z