Single dose of glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses
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A single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains.Herpes Simplex Vaccines: Prospects of Live-attenuated HSV Vaccines to Combat Genital and Ocular infections.Animal models of herpes simplex virus immunity and pathogenesis.Analysis of the Protective Immunity Induced by Herpes Simplex Virus 1 Strain M3 with an Attenuated Phenotype Due to Mutations in the Viral ul7, ul41, and LAT Genes.Attenuated Phenotype and Immunogenic Characteristics of a Mutated Herpes Simplex Virus 1 Strain in the Rhesus Macaque.
P2860
Single dose of glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Single dose of glycoprotein K ...... T cell memory immune responses
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Single dose of glycoprotein K
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type
label
Single dose of glycoprotein K ...... T cell memory immune responses
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Single dose of glycoprotein K
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prefLabel
Single dose of glycoprotein K ...... T cell memory immune responses
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Single dose of glycoprotein K
@nl
P2093
P2860
P356
P1433
P1476
Single dose of glycoprotein K ...... T cell memory immune responses
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P2093
Arun V Iyer
Jason D Walker
Konstantin G Kousoulas
Vladimir N Chouljenko
P2860
P356
10.1186/1743-422X-10-317
P577
2013-10-28T00:00:00Z