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The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein familyNMR solution structure of the activation domain of human procarboxypeptidase A2The impact of extra-domain structures and post-translational modifications in the folding/misfolding behaviour of the third PDZ domain of MAGUK neuronal protein PSD-95.Protein secondary structure and stability determined by combining exoproteolysis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Thermodynamic analysis of helix-engineered forms of the activation domain of human procarboxypeptidase A2.Hydrogen exchange monitored by MALDI-TOF mass spectrometry for rapid characterization of the stability and conformation of proteins.Monitoring disappearance of monomers and generation of resistance to proteolysis during the formation of the activation domain of human procarboxypeptidase A2 (ADA2h) amyloid fibrils by matrix-assisted laser-desorption ionization-time-of-flight-MS.The interconversion between a flexible β-sheet and a fibril β-arrangement constitutes the main conformational event during misfolding of PSD95-PDZ3 domainThe chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from marine bacterium Vibrio sp FC509 is a dimeric species: Biophysical characterization of an endosulfatase.Functional inclusion bodies produced in the yeast Pichia pastoris.Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment.Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease.Electronegative low-density lipoprotein. A link between apolipoprotein B misfolding, lipoprotein aggregation and proteoglycan binding.Protein structures in Alzheimer's disease: The basis for rationale therapeutic design.Production of an anti-Aβ antibody fragment in Pichia pastoris and in vitro and in vivo validation of its therapeutic effect.Aβ-Immunotherapeutic strategies: a wide range of approaches for Alzheimer's disease treatment.An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway.Cerebellar cortex development in the weaver condition presents regional and age-dependent abnormalities without differences in Purkinje cells neurogenesis.Influence of aggregation propensity and stability on amyloid fibril formation as studied by Fourier transform infrared spectroscopy and two-dimensional COS analysis.Early kinetics of amyloid fibril formation reveals conformational reorganisation of initial aggregates.Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils.Evidence for a two-state transition in the folding process of the activation domain of human procarboxypeptidase A2.Protein engineering as a strategy to avoid formation of amyloid fibrils2D-NMR reveals different populations of exposed lysine residues in the apoB-100 protein of electronegative and electropositive fractions of LDL particlesAggregated electronegative low density lipoprotein in human plasma shows a high tendency toward phospholipolysis and particle fusion.Favourable native-like helical local interactions can accelerate protein folding.The unfolding pathway of leech carboxypeptidase inhibitor.Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B.Prediction of a new class of RNA recognition motif.The activation pathway of procarboxypeptidase B from porcine pancreas: participation of the active enzyme in the proteolytic processing.Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency.Common features in the unfolding and misfolding of PDZ domains and beyond: the modulatory effect of domain swapping and extra-elements.Impaired binding affinity of electronegative low-density lipoprotein (LDL) to the LDL receptor is related to nonesterified fatty acids and lysophosphatidylcholine content.Principal component and cluster analysis of morphological variables reveals multiple discrete sub-phenotypes in weaver mouse mutants.Novel phospholipolytic activities associated with electronegative low-density lipoprotein are involved in increased self-aggregation.Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria.A thermodynamic study of the third PDZ domain of MAGUK neuronal protein PSD-95 reveals a complex three-state folding behavior.Effects of an Aβ-antibody fragment on Aβ aggregation and astrocytic uptake are modulated by apolipoprotein E and J mimetic peptides.Mapping the pro-region of carboxypeptidase B by protein engineering. Cloning, overexpression, and mutagenesis of the porcine proenzyme.An Intracellular Amyloid-β/AβPP Epitope Correlates with Neurodegeneration in those Neuronal Populations Early Involved in Alzheimer's Disease.
P50
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P50
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hulumtuese
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հետազոտող
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Sandra Villegas
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Sandra Villegas
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Sandra Villegas
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Sandra Villegas
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Sandra Villegas
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Sandra Villegas
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Sandra Villegas
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Sandra Villegas
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Sandra Villegas
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Sandra Villegas
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Virtudes Villegas
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Sandra Villegas
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Sandra Villegas
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Sandra Villegas
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Sandra Villegas
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Sandra Villegas
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P21
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