Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.
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Beta class II tubulin predominates in normal and tumor breast tissues.Class III β-tubulin counteracts the ability of paclitaxel to inhibit cell migrationNew insights into mechanisms of resistance to microtubule inhibitorsModulation of paclitaxel resistance by annexin IV in human cancer cell linesStabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option?Biomarkers of head and neck cancer, tools or a gordian knot?A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in DogsExploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics SimulationsHigh expression of class III β-tubulin predicts good response to neoadjuvant taxane and doxorubicin/cyclophosphamide-based chemotherapy in estrogen receptor-negative breast cancerAnticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl-dextran-MMA graft copolymer and paclitaxel used as an artificial enzymeMicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agentsβIII-Tubulin: biomarker of taxane resistance or drug target?Modulation of endogenous beta-tubulin isotype expression as a result of human beta(III)cDNA transfection into prostate carcinoma cellsAmitozyn impairs chromosome segregation and induces apoptosis via mitotic checkpoint activationParallel evolution under chemotherapy pressure in 29 breast cancer cell lines results in dissimilar mechanisms of resistancePaclitaxel resistance in untransformed human mammary epithelial cells is associated with an aneuploidy-prone phenotype.Alterations in ovarian cancer cell adhesion drive taxol resistance by increasing microtubule dynamics in a FAK-dependent manner.Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics.Proteome analysis of vinca alkaloid response and resistance in acute lymphoblastic leukemia reveals novel cytoskeletal alterations.TP53 status and taxane-platinum versus platinum-based therapy in ovarian cancer patients: a non-randomized retrospective study.The Extracellular Matrix in Epithelial Ovarian Cancer - A Piece of a Puzzle.Class III β-tubulin is a predictive marker for taxane-based chemotherapy in recurrent and metastatic gastric cancerClass III beta-tubulin expression and in vitro resistance to microtubule targeting agents.Rescue of paclitaxel sensitivity by repression of Prohibitin1 in drug-resistant cancer cellsBeta tubulin affects the aryl hydrocarbon receptor function via an Arnt-mediated mechanism.Mechanisms of Taxol resistance related to microtubules.Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxolMicrotubules and their role in cellular stress in cancerDocetaxel-carboxymethylcellulose nanoparticles display enhanced anti-tumor activity in murine models of castration-resistant prostate cancer.Thymidine Phosphorylase/β-tubulin III expressions predict the response in Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel.Quantification and expert evaluation of evidence for chemopredictive biomarkers to personalize cancer treatment.Paclitaxel-induced cell death: where the cell cycle and apoptosis come together.Mechanisms of action and resistance to tubulin-binding agents.Higher sensitivity to patupilone versus paclitaxel chemotherapy in primary uterine serous papillary carcinoma cell lines with high versus low HER-2/neu expression in vitro.Drug discovery targeting cell division proteins, microtubules and FtsZ.Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen.Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer.A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy.Preclinical profile of cabazitaxel.Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities.
P2860
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P2860
Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1997
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Taxol-resistant epithelial ova ...... pecific beta-tubulin isotypes.
@en
Taxol-resistant epithelial ova ...... pecific beta-tubulin isotypes.
@nl
type
label
Taxol-resistant epithelial ova ...... pecific beta-tubulin isotypes.
@en
Taxol-resistant epithelial ova ...... pecific beta-tubulin isotypes.
@nl
prefLabel
Taxol-resistant epithelial ova ...... pecific beta-tubulin isotypes.
@en
Taxol-resistant epithelial ova ...... pecific beta-tubulin isotypes.
@nl
P2093
P2860
P356
P1476
Taxol-resistant epithelial ova ...... pecific beta-tubulin isotypes.
@en
P2093
C A Burkhart
M D Norris
M Kavallaris
S B Horwitz
P2860
P304
P356
10.1172/JCI119642
P407
P577
1997-09-01T00:00:00Z