Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain
about
Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitisLong-term potentiation in the anterior cingulate cortex and chronic painGlutamate receptor ion channels: structure, regulation, and functionNovel epigallocatechin-3-gallate (EGCG) derivative as a new therapeutic strategy for reducing neuropathic pain after chronic constriction nerve injury in miceEffects of electroacupuncture in a mouse model of fibromyalgia: role of N-methyl-D-aspartate receptors and related mechanisms.Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.2020 Foresight: Envisioning Therapeutic Innovations for Pain.Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.Cortical NR2B NMDA subunit antagonism reduces inflammatory pain in male and female ratsPalmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice.Memantine before Mastectomy Prevents Post-Surgery Pain: A Randomized, Blinded Clinical Trial in Surgical Patients.A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain.Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators.Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptorsNR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning.NMDA Receptor Antagonists for Treatment of DepressionCharacterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording.Carbon monoxide: a gas that modulates nociception.Neuronal and microglial mechanisms of neuropathic painPharmacokinetic and pharmacodynamic considerations for NMDA receptor antagonists in the treatment of chronic neuropathic pain.Opioid administration following spinal cord injury: implications for pain and locomotor recovery.Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome.Calcium-permeable ion channels in pain signaling.Neuronal calcium signaling in chronic pain.Rapid Management of Trigeminal Neuralgia and Comorbid Major Depressive Disorder With Duloxetine.Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain.Peripheral inflammation activated focal adhesion kinase signaling in spinal dorsal horn of mice.Longistyline C acts antidepressant in vivo and neuroprotection in vitro against glutamate-induced cytotoxicity by regulating NMDAR/NR2B-ERK pathway in PC12 cellsGluN2B N-methyl-D-aspartate receptor and excitatory amino acid transporter 3 are upregulated in primary sensory neurons after 7 days of morphine administration in rats: implication for opiate-induced hyperalgesia.Crystal structure of (1S*,2R*)-7-benz-yloxy-2-methyl-3-tosyl-2,3,4,5-tetra-hydro-1H-3-benz-azepin-1-ol: elucidation of the relative configuration of potent allosteric GluN2B selective NMDA receptor antagonists.No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex.Novel GluN2B selective NMDA receptor antagonists: relative configuration of 7-meth-oxy-2-methyl-2,3,4,5-tetra-hydro-1H-3-benzazepin-1-ols.Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment.Maternal separation stress leads to resilience against neuropathic pain in adulthood.Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice.The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions.Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1β-induced thermal hyperalgesia in rats.Chronic pain and impaired glial glutamate transporter function in lupus-prone mice are ameliorated by blocking macrophage colony-stimulating factor-1 receptors.D-Aspartate drinking solution alleviates pain and cognitive impairment in neuropathic mice.Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats.
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P2860
Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain
@en
Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain.
@nl
type
label
Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain
@en
Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain.
@nl
prefLabel
Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain
@en
Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain.
@nl
P2860
P1433
P1476
Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain
@en
P2093
P2860
P2888
P304
P356
10.1016/J.NURT.2009.07.008
P577
2009-10-01T00:00:00Z
P5875
P6179
1012173478