Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis
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Molecular mechanism for human sperm chemotaxis mediated by progesteroneMultiple roles for the actin cytoskeleton during regulated exocytosisDistinct initial SNARE configurations underlying the diversity of exocytosisADP ribosylation factor 6 (ARF6) promotes acrosomal exocytosis by modulating lipid turnover and Rab3A activation.Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm.Unresolved questions concerning mammalian sperm acrosomal exocytosis.Signaling in sperm: toward a molecular understanding of the acquisition of sperm motility in the mouse epididymis.α-SNAP prevents docking of the acrosome during sperm exocytosis because it sequesters monomeric syntaxin.beta-Adrenergic activation of electrogenic K+ and Cl- secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways.Calcium channels in the development, maturation, and function of spermatozoa.Epac, Rap and Rab3 act in concert to mobilize calcium from sperm's acrosome during exocytosiscAMP and EPAC are key players in the regulation of the signal transduction pathway involved in the α-hemolysin autophagic responseIdentification and function of exchange proteins activated directly by cyclic AMP (Epac) in mammalian spermatozoa.Central role of soluble adenylyl cyclase and cAMP in sperm physiology.Cannabinoid type 1 receptors transiently silence glutamatergic nerve terminals of cultured cerebellar granule cells.Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility.cAMP-mediated secretion of brain-derived neurotrophic factor in developing airway smooth muscle.Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa.Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cellsRab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosisβ-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.Compartmentalization of distinct cAMP signaling pathways in mammalian spermRoles of intracellular cyclic AMP signal transduction in the capacitation and subsequent hyperactivation of mouse and boar spermatozoaAdenylyl cyclases in the digestive system.The proteins of exocytosis: lessons from the sperm model.The Molecules of Sperm Exocytosis.A strong host response and lack of MYC expression are characteristic for diffuse large B cell lymphoma transformed from nodular lymphocyte predominant Hodgkin lymphomaCellular mechanisms of plasmalemmal sealing and axonal repair by polyethylene glycol and methylene blue.Pathways for plasmalemmal repair mediated by PKA, Epac, and cytosolic oxidation in rat B104 cells in vitro and rat sciatic axons ex vivo.Identification of EPAC (Exchange Protein Activated by cAMP) bioinformatically as a potential signalling biomarker in Cardiovascular Disease (CVD) and its molecular docking by a lead molecule.The dynamic plasticity of insulin production in β-cells.GTP-bound Rab3A exhibits consecutive positive and negative roles during human sperm dense-core granule exocytosis.The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores.Rab3a-Bound CD63 Is Degraded and Rab3a-Free CD63 Is Incorporated into HIV-1 Particles.CB1 receptors down-regulate a cAMP/Epac2/PLC pathway to silence the nerve terminals of cerebellar granule cells.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Inhibition of Epac2 Attenuates Neural Cell Apoptosis and Improves Neurological Deficits in a Rat Model of Traumatic Brain Injury.How Rap and its GEFs control liver physiology and cancer development. C3G alterations in human hepatocarcinoma
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P2860
Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 22 June 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis
@en
Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis.
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type
label
Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis
@en
Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis.
@nl
prefLabel
Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis
@en
Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis.
@nl
P2093
P2860
P356
P1476
Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis
@en
P2093
Alberto Darszon
Claudia N Tomes
Gerardo A De Blas
Holger Rehmann
Luis S Mayorga
María T Branham
Matías A Bustos
Valeria E P Zarelli
P2860
P304
24825-24839
P356
10.1074/JBC.M109.015362
P407
P577
2009-06-22T00:00:00Z