Physical requirements and functional consequences of complex formation between the cytomegalovirus IE1 protein and human STAT2. - Wikidata - thesis-toulmin - TriplyDB

Physical requirements and functional consequences of complex formation between the cytomegalovirus IE1 protein and human STAT2.

Physical requirements and functional consequences of complex formation between the cytomegalovirus IE1 protein and human STAT2.

http://www.wikidata.org/entity/Q37452497

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Human cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expression Analysis of human cytomegalovirus-encoded SUMO targets and temporal regulation of SUMOylation of the immediate-early proteins IE1 and IE2 during infection Controlled crystal dehydration triggers a space-group switch and shapes the tertiary structure of cytomegalovirus immediate-early 1 (IE1) protein Human cytomegalovirus major immediate early 1 protein targets host chromosomes by docking to the acidic pocket on the nucleosome surface.The carboxy terminal region of the human cytomegalovirus immediate early 1 (IE1) protein disrupts type II inteferon signaling.Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-γ Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions.Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment.Evidence for a dual antiviral role of the major nuclear domain 10 component Sp100 during the immediate-early and late phases of the human cytomegalovirus replication cycle Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus.Single Chain Antibodies Against gp55 of Human Cytomegalovirus (HCMV) for Prophylaxis and Treatment of HCMV Infections.Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators.Histone H3 lysine 4 methylation marks postreplicative human cytomegalovirus chromatin.Characterization of Recombinant Human Cytomegaloviruses Encoding IE1 Mutants L174P and 1-382 Reveals that Viral Targeting of PML Bodies Perturbs both Intrinsic and Innate Immune Responses Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus.The tiers and dimensions of evasion of the type I interferon response by human cytomegalovirus.Identification of cellular proteins that interact with human cytomegalovirus immediate-early protein 1 by protein array assay.How to control an infectious bead string: nucleosome-based regulation and targeting of herpesvirus chromatin.The human cytomegalovirus major immediate-early proteins as antagonists of intrinsic and innate antiviral host responses.Interferons as biomarkers and effectors: lessons learned from animal models.Interplay between CMVs and interferon signaling: implications for pathogenesis and therapeutic intervention.Attack, parry and riposte: molecular fencing between the innate immune system and human herpesviruses.Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome.The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting.The proteome of human cytomegalovirus virions and dense bodies is conserved across different strains.The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies.Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase.Modular cell-based platform for high throughput identification of compounds that inhibit a viral interferon antagonist of choice.Human cytomegalovirus UL23 inhibits transcription of interferon-γ stimulated genes and blocks antiviral interferon-γ responses by interacting with human N-myc interactor protein.Transmembrane protein pUL50 of human cytomegalovirus inhibits ISGylation by downregulating UBE1L.

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Physical requirements and functional consequences of complex formation between the cytomegalovirus IE1 protein and human STAT2.

http://www.wikidata.org/entity/Q37452497

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 07 October 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Physical requirements and func ...... s IE1 protein and human STAT2.

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Physical requirements and func ...... s IE1 protein and human STAT2.

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type

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Physical requirements and func ...... s IE1 protein and human STAT2.

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Physical requirements and func ...... s IE1 protein and human STAT2.

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prefLabel

Physical requirements and func ...... s IE1 protein and human STAT2.

@en

Physical requirements and func ...... s IE1 protein and human STAT2.

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Journal of Virology

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Physical requirements and func ...... s IE1 protein and human STAT2.

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Christina Paulus

http://www.w3.org/2001/XMLSchema#string

Julia Kaps

http://www.w3.org/2001/XMLSchema#string

Michael Nevels

http://www.w3.org/2001/XMLSchema#string

Nathalie Czech

http://www.w3.org/2001/XMLSchema#string

Steffen Krauss

http://www.w3.org/2001/XMLSchema#string

P2860

Intrinsically unstructured proteins and their functions

Function and structure of inherently disordered proteins

Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus

Acetylation-dependent signal transduction for type I interferon receptor

PML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0

Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections

Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption

Proteasome-independent disruption of PML oncogenic domains (PODs), but not covalent modification by SUMO-1, is required for human cytomegalovirus immediate-early protein IE1 to inhibit PML-mediated transcriptional repression.

Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expression

Ability of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cells

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12854-12870

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scholarly article

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10.1128/JVI.01164-09

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24

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83

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2009-10-07T00:00:00Z

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19812155

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Cytomegalovirus

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2786848

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