An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals.
about
Molecular mechanisms of the whole DNA repair system: a comparison of bacterial and eukaryotic systemsWhy does obesity promote cancer? Epidemiology, biology, and open questionsMass spectrometry for the assessment of the occurrence and biological consequences of DNA adductsIrreversible inhibition of DNA polymerase beta by an oxidized abasic lesion.Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxideOn the formation and properties of interstrand DNA-DNA cross-links forged by reaction of an abasic site with the opposing guanine residue of 5'-CAp sequences in duplex DNA.Modulation of trinucleotide repeat instability by DNA polymerase β polymorphic variant R137Q.Chemical Biology of N5-Substituted Formamidopyrimidine DNA Adducts.Direct strand scission from a nucleobase radical in RNAProduct and mechanistic analysis of the reactivity of a C6-pyrimidine radical in RNA.Interstrand cross-links arising from strand breaks at true abasic sites in duplex DNA.Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesisInhibition of short patch and long patch base excision repair by an oxidized abasic site.Recent advances in the structural mechanisms of DNA glycosylasesRestricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient miceA 5', 8-cyclo-2'-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase βCovalent adduct formation between the antihypertensive drug hydralazine and abasic sites in double- and single-stranded DNA.Spirodi(iminohydantoin) products from oxidation of 2'-deoxyguanosine in the presence of NH4Cl in nucleoside and oligodeoxynucleotide contexts.Repair of the major lesion resulting from C5'-oxidation of DNA.Hydrolytic Fitness of N-glycosyl Bonds: Comparing the Deglycosylation Kinetics of Modified, Alternative and Native NucleosidesProbing DNA interstrand cross-link formation by an oxidized abasic site using nonnative nucleotidesEfficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications.Chemical and structural characterization of interstrand cross-links formed between abasic sites and adenine residues in duplex DNA.Thiol-activated DNA damage by α-bromo-2-cyclopentenone.DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide.Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.A simple, high-yield synthesis of DNA duplexes containing a covalent, thermally cleavable interstrand cross-link at a defined locationThe macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural productCHEMICAL SELECTIVITY OF NUCLEOBASE ADDUCTION RELATIVE TO IN VIVO MUTATION SITES ON EXON 7 FRAGMENT OF P53 TUMOR SUPPRESSOR GENECrown ether-electrolyte interactions permit nanopore detection of individual DNA abasic sites in single moleculesGeneration of DNA-damaging reactive oxygen species via the autoxidation of hydrogen sulfide under physiologically relevant conditions: chemistry relevant to both the genotoxic and cell signaling properties of H(2)SDNA Polymerases ImuC and DinB Are Involved in DNA Alkylation Damage Tolerance in Pseudomonas aeruginosa and Pseudomonas putidaIdentification of DNA lesions using a third base pair for amplification and nanopore sequencing.Chemical structure and properties of interstrand cross-links formed by reaction of guanine residues with abasic sites in duplex DNALanthanide ions as required cofactors for DNA catalysts.Synthesis and characterization of a small analogue of the anticancer natural product leinamycin.DNA polymerase λ inactivation by oxidized abasic sites.pH-Dependent Equilibrium between 5-Guanidinohydantoin and Iminoallantoin Affects Nucleotide Insertion Opposite the DNA Lesion.Characterization of Interstrand DNA-DNA Cross-Links Using the α-Hemolysin Protein Nanopore
P2860
Q24630140-1D9D3C53-61AE-4177-BC39-CC1DA4366C78Q26797301-D92DB4A5-6947-46DD-AF78-0D319BC6E74CQ28082391-3FF200EB-9C98-464D-BCCA-1383776FC6CEQ33545372-A00D2939-FCF2-4BF6-82C5-12FAFDEFE5F1Q33575435-CB245DCD-3801-4AB8-B29E-43ACA42B18B1Q33575462-F793E73E-579D-4FD6-B0F7-8EA67B86C67BQ33643405-E79F98E4-D4D7-4E5C-BE94-065630566BDAQ33649473-ECCF317A-5EF7-448B-80A5-AB10AEE1A600Q33752961-2032DA86-C41D-4D38-8131-BBF8E9F878FFQ33842544-546BAD9F-7AA6-4087-81A0-CA90CA50001BQ33879129-F4180A99-7E37-4814-B124-2B4AD9981361Q34061361-FE9F5C1A-20DD-4EE7-82E9-5C4DE4093185Q34132791-94E75E2B-A9D0-4A2A-A005-2B59FE13598CQ34293010-C2D744E9-65E3-4D03-8A7F-725EBED5093DQ34306735-724BC827-F39B-4165-B1D3-7C9032A99CF5Q34538349-89A6BDB7-97B0-45C8-9F79-BB59E66113F9Q34712058-332BE983-EE41-47DE-9C4C-A4F653FD39B1Q34724245-E1B01732-935B-45AE-B8C0-1D52DCB419CCQ34992472-60C2C662-678C-4EAE-9CA4-B0D965073E6FQ35106795-75B24DD3-1641-4AE9-B1D2-4D0C6C87A9A4Q35146104-1A531F48-8480-4296-AE18-EFDBCAC5A2DAQ35223940-3069783D-A38C-495D-9AAB-F69F04BE4A9BQ35230177-585F80BE-C0D0-4AB6-A74C-FC405119E12DQ35476294-6E70EDFD-0ED7-45D8-80D0-C02A0A0490C7Q35707712-BE8CE3C7-6CF0-48B2-8028-4351574EC7FDQ35707721-B66EED71-EFA3-424B-A2FF-663E23CD10FEQ35707736-899D4A26-9090-404A-97B0-CF3EF5E2413EQ35939974-958D0B1D-4981-4009-8F4F-5688EBD6BB10Q36036274-E3BEABF8-CE0E-481D-9A88-0346777308DBQ36093540-F8E69109-A26B-4B04-B313-D9ECBA445CA4Q36122781-BBC78414-8855-4087-A743-221272E94886Q36177007-D501C469-24C1-4301-9D28-98D27E1F5AB0Q36258789-D8414013-ABB0-46CD-AB28-863D2407CEA8Q36341399-F9B83756-A102-44C2-BF35-B4A5FA4C10C9Q36444967-B67A580F-53F0-4D62-BF70-C84CF554E12EQ36464736-FE8316D6-2066-4523-BFC7-A5FAB9FB85ABQ36495994-486F0816-7ADA-4686-B1DA-5837A4CD4E14Q36593556-B06476B8-4D9B-4030-B8F5-055A716A4EF0Q36714153-38C505C0-A770-42DE-8770-B2C4729956C9Q36784137-6BA23740-33CD-4397-8F30-442E3BAF38DE
P2860
An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
An overview of chemical proces ...... , and reactions with radicals.
@en
An overview of chemical proces ...... , and reactions with radicals.
@nl
type
label
An overview of chemical proces ...... , and reactions with radicals.
@en
An overview of chemical proces ...... , and reactions with radicals.
@nl
prefLabel
An overview of chemical proces ...... , and reactions with radicals.
@en
An overview of chemical proces ...... , and reactions with radicals.
@nl
P2860
P356
P1476
An overview of chemical proces ...... , and reactions with radicals.
@en
P2093
Kent S Gates
P2860
P304
P356
10.1021/TX900242K
P577
2009-11-01T00:00:00Z