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Pharmacotherapy for the management of achalasia: Current status, challenges and future directionsCurrent status and future directions of botulinum neurotoxins for targeting pain processingObstructing toxin pathways by targeted pore blockageEmerging opportunities for serotypes of botulinum neurotoxinsOn botulinum neurotoxin variabilityDevelopment of onabotulinumtoxinA for chronic migraineBotulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neuronsStructural analysis of the receptor binding domain of botulinum neurotoxin serotype DCrystal structure of the receptor binding domain of the botulinum C–D mosaic neurotoxin reveals potential roles of lysines 1118 and 1136 in membrane interactionsThe biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sitesBotulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell EntryStructures of engineeredClostridium botulinumneurotoxin derivativesStructural insights into the functional role of the Hcn sub-domain of the receptor-binding domain of the botulinum neurotoxin mosaic serotype C/DBotulinum Neurotoxin Is Shielded by NTNHA in an Interlocked ComplexStructure of dual receptor binding to botulinum neurotoxin BCrystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and IIStructural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin ABotulinum Toxin as a Pain Killer: Players and Actions in AntinociceptionBotulinum neurotoxin serotype A specific cell-based potency assay to replace the mouse bioassayPhosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based AssaysHuman synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicityIdentification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin AAtoxic derivative of botulinum neurotoxin A as a prototype molecular vehicle for targeted delivery to the neuronal cytoplasmBotulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins.Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.Hybrid compounds: from simple combinations to nanomachines.Preferential entry of botulinum neurotoxin A Hc domain through intestinal crypt cells and targeting to cholinergic neurons of the mouse intestineSNARE tagging allows stepwise assembly of a multimodular medicinal toxin.The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival.The Microbial OlympicsTherapeutic use of botulinum toxin in migraine: mechanisms of action.Hapten mediated display and pairing of recombinant antibodies accelerates assay assembly for biothreat countermeasuresRole of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen.Sensitive and quantitative detection of botulinum neurotoxin in neurons derived from mouse embryonic stem cells.Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1Neuronal targeting, internalization, and biological activity of a recombinant atoxic derivative of botulinum neurotoxin A.Botulinum neurotoxin type A is internalized and translocated from small synaptic vesicles at the neuromuscular junction.Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
gotara zanistî
@ku-latn
scientific article published on January 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
name
Botulinum neurotoxin: a marvel of protein design.
@en
Botulinum neurotoxin: a marvel of protein design.
@nl
type
label
Botulinum neurotoxin: a marvel of protein design.
@en
Botulinum neurotoxin: a marvel of protein design.
@nl
prefLabel
Botulinum neurotoxin: a marvel of protein design.
@en
Botulinum neurotoxin: a marvel of protein design.
@nl
P1476
Botulinum neurotoxin: a marvel of protein design.
@en
P2093
Mauricio Montal
P304
P356
10.1146/ANNUREV.BIOCHEM.051908.125345
P577
2010-01-01T00:00:00Z