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Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channelFunctional analysis of missense variants in the TRESK (KCNK18) K channelRediscovering area CA2: unique properties and functionsK2P channel gating mechanisms revealed by structures of TREK-2 and a complex with ProzacThe acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking.Potassium channels in articular chondrocytesThe role of pH-sensitive TASK channels in central respiratory chemoreception.Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance.Nonmigraine-associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons.The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel.Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9.Multiple modalities converge on a common gate to control K2P channel function.Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykininTASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion.External Ba2+ block of the two-pore domain potassium channel TREK-1 defines conformational transition in its selectivity filter.S100 calcium binding proteins and ion channelsPharmacogenetic diversification by alternative translation initiation: background channels to the fore.A unique alkaline pH-regulated and fatty acid-activated tandem pore domain potassium channel (K₂P) from a marine sponge.Functional transcriptomics of a migrating cell in Caenorhabditis elegans.Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidificationModulation of Potassium Channels Inhibits Bunyavirus Infection.Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels.The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESKMolecular physiology of pH-sensitive background K(2P) channels.Polycystins and partners: proposed role in mechanosensitivity.Diverse mechanisms underlying the regulation of ion channels by carbon monoxide.Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain.The role of K₂p channels in anaesthesia and sleep.The family of K2P channels: salient structural and functional properties.Much more than a leak: structure and function of K₂p-channels.The pore structure and gating mechanism of K2P channels.Acid sensitive background potassium channels K2P3.1 and K2P9.1 undergo rapid dynamin-dependent endocytosis.Enhancement of TWIK-related acid-sensitive potassium channel 3 (TASK3) two-pore domain potassium channel activity by tumor necrosis factor α.Chansporter complexes in cell signaling.Nicotine inhibits potassium currents in Aplysia bag cell neurons.State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1Grafting voltage and pharmacological sensitivity in potassium channelsKCNK10, a tandem pore domain potassium channel, is a regulator of mitotic clonal expansion during the early stage of adipocyte differentiation.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 June 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Gating of two pore domain potassium channels.
@en
Gating of two pore domain potassium channels.
@nl
type
label
Gating of two pore domain potassium channels.
@en
Gating of two pore domain potassium channels.
@nl
prefLabel
Gating of two pore domain potassium channels.
@en
Gating of two pore domain potassium channels.
@nl
P2860
P1476
Gating of two pore domain potassium channels
@en
P2093
Ehab Al-Moubarak
P2860
P304
P356
10.1113/JPHYSIOL.2010.192344
P407
P577
2010-06-21T00:00:00Z