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Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1Essential roles of four-carbon backbone chemicals in the control of metabolismThe Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytesInsulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start siteRole of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesityCentral role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.Phosphoinositide 3-kinase signalling: no lipids.Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells.Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells.Modulation of insulin action.Adipocytes, like their progenitors, contribute to inflammation of adipose tissues through promotion of Th-17 cells and activation of monocytes, in obese subjects.Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans.Therapeutic potential of activators and inhibitors of sirtuins.Epigenetic phenomena linked to diabetic complications.Protein acetylation mechanisms in the regulation of insulin and insulin-like growth factor 1 signalling.Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways.Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport.Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats.Modulation of the vascular endothelium functioning by dietary components, the role of epigenetics.Dysregulation of sirtuins and key metabolic genes in skeletal muscle of pigs with spontaneous intrauterine growth restriction is associated with alterations of circulating IGF-1.Resveratrol is a class IA phosphoinositide 3-kinase inhibitor.Maternal protein restriction induced-hypertension is associated to oxidative disruption at transcriptional and functional levels in the medulla oblongata.Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.Dietary polyphenols and their effects on cell biochemistry and pathophysiology.Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the ADRB3 gene, lipid profile and oxidative stress in overweight or obese women.Phospholipase D2 regulates endothelial permeability through cytoskeleton reorganization and occludin downregulation.Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells.A special BioFactors issue dedicated to resveratrol.118th ENMC International Workshop on Advances in Myotubular Myopathy. 26-28 September 2003, Naarden, The Netherlands. (5th Workshop of the International Consortium on Myotubular Myopathy).The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation.Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells.Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients.Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats.Transcriptional response of skeletal muscle to a low protein perinatal diet in rat offspring at different ages: The role of key enzymes of glucose-fatty acid oxidation.[The new paradigm of the developmental origin of health and diseases (DOHaD)--Epigenetics and environment: evidence and missing links].[Epigenetics in transgenerational responses to environmental impacts: from facts and gaps].Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells.The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice.The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1.
P50
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P50
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հետազոտող
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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Luciano Pirola
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P106
P21
P31
P496
0000-0001-6539-5435